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Titolo:
Magnesium regulation of Ca2+ channels in smooth muscle and endothelial cells of human allantochorial placental vessels
Autore:
Bara, M; Guiet-Bara, A;
Indirizzi:
Univ Paris 06, Lab Physiopathol Implantat & Dev, F-75252 Paris 05, France Univ Paris 06 Paris France 05 Implantat & Dev, F-75252 Paris 05, France
Titolo Testata:
MAGNESIUM RESEARCH
fascicolo: 1-2, volume: 14, anno: 2001,
pagine: 11 - 18
SICI:
0953-1424(200103)14:1-2<11:MROCCI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR MG2+; CALCIUM CHANNELS; MEMBRANE; CONTRACTILITY; POTASSIUM; CURRENTS; AGENTS; SALTS; ENTRY; IONS;
Keywords:
calcium channels; endothelial cells; human placenta; MgCl2; MgSO4; smooth muscle cells; vessels;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Bara, M Univ Paris 06, Reprod Physiol Lab, Batiment A,4 Pl Jussieu, F-75252 Paris 05, France Univ Paris 06 Batiment A,4 Pl Jussieu Paris France 05 05, France
Citazione:
M. Bara e A. Guiet-Bara, "Magnesium regulation of Ca2+ channels in smooth muscle and endothelial cells of human allantochorial placental vessels", MAGNES RES, 14(1-2), 2001, pp. 11-18

Abstract

In human allantochorial placental vessels, the vascular tone is regulated by membrane potential controlled by the ion flux through K+ and Ca2+ channels. The effects of MgCl2 and MgSO4 were studied on the membrane potential of vascular smooth muscle cells [VSMCs) and of endothelial cells (VECs). Themembrane potential was the main factor of the excitation-contraction coupling of placental vessels. The VSMCs and VECs were predepolarized by high external K+, which blocked voltage-sensitive K+ channels, and depolarized by serotonin addition which activated Ca2+ influx through voltage-gated Ca2+ channels. Addition of MgCl2 or MgSO4 in the external medium induced a depolarization level lower than the previous level, as nifedipine a Ca2+ blocker,corresponding to a Ca2+ influx reduction in VSMCs and VECs and inducing relaxation of the cells. The effect of MgCl2 and MgSO4 was the same on VSMCs and VECs, but the depolarization level reduction was more important with MgCl2 than MgSO4 on VSMCs. These data suggest ed that Mg salts regulated the Ca2+ influx through voltage-gated Ca2+ channels in VSMCs and VECs and consequently the tonus of human allantochorial placental vessels and that there was a difference between Mg salts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:06:11