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Titolo:
Lovastatin induced control of blast cell growth in an elderly patient withacute myeloblastic leukemia
Autore:
Minden, MD; Dimitroulakos, J; Nohynek, D; Penn, LZ;
Indirizzi:
Univ Hlth Network, Ontario Canc Inst, Dept Cellular & Mol Biol, Toronto, ON M5G 2M9, Canada Univ Hlth Network Toronto ON Canada M5G 2M9 , Toronto, ON M5G 2M9, Canada
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 5-6, volume: 40, anno: 2001,
pagine: 659 - 662
SICI:
1042-8194(200102)40:5-6<659:LICOBC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEVALONATE PATHWAY;
Keywords:
lovastatin; AML; case report;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Penn, LZ Univ Hlth Network, Ontario Canc Inst, Dept Cellular & Mol Biol, 610 Univ Ave, Toronto, ON M5G 2M9, Canada Univ Hlth Network 610 Univ Ave Toronto ON Canada M5G 2M9 , Canada
Citazione:
M.D. Minden et al., "Lovastatin induced control of blast cell growth in an elderly patient withacute myeloblastic leukemia", LEUK LYMPH, 40(5-6), 2001, pp. 659-662

Abstract

We recently reported that AML cells derived either from cell lines or frompatients undergo apoptosis in response to lovastatin, an agent used extensively in the treatment of hypercholesterolemia. The concentration of lovastatin required to achieve this in culture varies from patient to patient, however, the in vitro concentrations required to kill AML cells, can be attained clinically. While in vitro studies assessing responsiveness of leukemiccells to lovastatin were being performed, a 72 year old female presented with relapsed AML. The patient did not desire any further induction therapy. As the patient's cells proved to he sensitive in culture to lovastatin, the patient was offered this drug. In this brief report we describe a case inwhich there was apparent control of the patient's leukemic blast cells by lovastatin at a dose double the usual recommended dose for hypercholesterolemia. This case illustrates the potential for lovastatin to provide a novelmeans of controlling leukemic cell growth in AML patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/08/20 alle ore 14:12:44