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Titolo:
Second primary tumors and immune phenomena after fludarabine or 2-chloro-2'-deoxyadenosine treatment
Autore:
Van den Neste, E; Delannoy, A; Feremans, W; Ferrant, A; Michaux, L;
Indirizzi:
Univ Catholique Louvain, Clin Univ St Luc, Dept Hematol, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 5-6, volume: 40, anno: 2001,
pagine: 541 - 550
SICI:
1042-8194(200102)40:5-6<541:SPTAIP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-LYMPHOCYTIC-LEUKEMIA; HAIRY-CELL LEUKEMIA; AUTOIMMUNE HEMOLYTIC-ANEMIA; NON-HODGKINS-LYMPHOMA; TERM FOLLOW-UP; EPSTEIN-BARR-VIRUS; ACUTE MYELOID-LEUKEMIA; LOW-DOSE FLUDARABINE; VERSUS-HOST DISEASE; 2-CHLORODEOXYADENOSINE CLADRIBINE;
Keywords:
fludarabine; cladribine; 2-chloro-2 '-deoxyadenosine; complication;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Van den Neste, E Univ Catholique Louvain, Clin Univ St Luc, Dept Hematol, 10 Av Hippocrate,B-1200 Brussels, Belgium Univ Catholique Louvain 10 Av Hippocrate Brussels Belgium B-1200
Citazione:
E. Van den Neste et al., "Second primary tumors and immune phenomena after fludarabine or 2-chloro-2'-deoxyadenosine treatment", LEUK LYMPH, 40(5-6), 2001, pp. 541-550

Abstract

The purine nucleoside analogs fludarabine and 2-chloro-2'-deoxyadenosine display substantial activity in the treatment of various chronic lymphoproliferative disorders. Their major toxicities are primarily immunosuppression and myelosuppression. The profound influence of these drugs on the immune system has raised questions as to the emergence of secondary neoplasms or auto-immune disorders after their use. Based on a literature review and on personal observations, this article reviews the potential clinical importanceof these concerns.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:50:08