Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Continuous infusion of vincristine-doxorubicin with bolus of Dexamethasone(VAD) alternated with CHEP in the treatment of patients over 60 years old with aggressive non-Hodgkin's lymphoma
Autore:
Cartron, G; Voillat, L; Desablens, B; Le Maignan, C; Milpied, N; Foussard, C; Dugay, J; Maakaroun, A; De Muret, A; Colombat, P;
Indirizzi:
Dept Hematol, Tours, France Dept Hematol Tours FranceDept Hematol, Tours, France
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 5-6, volume: 40, anno: 2001,
pagine: 529 - 540
SICI:
1042-8194(200102)40:5-6<529:CIOVWB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
STANDARD REGIMEN CHOP; COMBINATION CHEMOTHERAPY REGIMEN; CONTINUOUS INTRAVENOUS-INFUSION; DIFFUSE HISTIOCYTIC LYMPHOMA; COLONY-STIMULATING FACTOR; ELDERLY PATIENTS; MULTIPLE-MYELOMA; CELL LYMPHOMAS; PHASE-II; EUROPEAN ORGANIZATION;
Keywords:
non Hodgkin's lymphoma; elderly patients; VAD; IPI; phenotype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Cartron, G CHRU Bretonneau, Serv Oncol Med & Malad Sang, 2 Blvd Tonnelle, F-37044 Tours, France CHRU Bretonneau 2 Blvd Tonnelle Tours France F-37044s, France
Citazione:
G. Cartron et al., "Continuous infusion of vincristine-doxorubicin with bolus of Dexamethasone(VAD) alternated with CHEP in the treatment of patients over 60 years old with aggressive non-Hodgkin's lymphoma", LEUK LYMPH, 40(5-6), 2001, pp. 529-540

Abstract

This prospective study was undertaken to evaluate the efficacy and toxicity of combination chemotherapy with alternating cycles of vincristine, doxorubicin and dexamethasone (VAD) and cyclophophamide, doxorubicin, etoposide and prednisone (CHEP) in patients over 60 years old with previously untreated and advanced non-Hodgkin's lymphoma (NHL) of intermediate- and high-grade malignancy. Eighty one consecutive, patients with NHL referred from April1992 to October 1997 to GOELAMS centers were enrolled in this study and their outcome updated to June 1, 1999. Of 81 enrolled patients, 77 were eligible and assessable for response. The median age was 70 years (61 to 78). 85.7% were stags III or IV, 39% were of performance status greater than or equal to 2, 27.3% greater than or equal to 2 involved extra-nodal sites and 57.3% had higher LDH levels than normal. The immunophenotype was B in 87% and T in 13%. Fifty-one (66.2%) patients received the scheduled eight cycles of therapy and treatment was withdrawn in only 6 patients (7.8%) because oftoxicity. Neutropenia grade 3-4 occurred in 11.1% after VAD courses vs 40.6% after CHEF courses. The mean cumulative dose of doxorubicin was 269 mg/m(2) and the relative dose intensity was 84%. The overall response and complete response rates were 66.2% and 51.9% respectively. and after a median follow-up of 52 months the 3 year overall survival (OS) and event-free survival rates (EFS) were 43.5% and 33.0% respectively. In multivariate analysis,OS and EFS were statistically influenced by IPI (p = 3 x 10(-3); p < 1 x 10(-4)) and phenotype (p = 2 x 10(-3): p < 1 x 10(-4)). Our findings supportthe alternation of 4 courses of VAD and CHEP as it is well tolerated in patients over 60 years old with advanced intermediate- or high-grade NHL and provides response and survival rates comparable to 6 courses of CHOP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:09:47