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Titolo:
PPP2R1B gene in chronic lymphocytic leukemias and mantle cell lymphomas
Autore:
Zhu, Y; Loukola, A; Monni, O; Kuokkanen, K; Franssila, K; Elonen, E; Vilpo, J; Joensuu, H; Kere, J; Aaltonen, L; Knuutila, S;
Indirizzi:
Univ Helsinki, Cent Hosp, Dept Med Genet, FIN-00029 Helsinki, Finland UnivHelsinki Helsinki Finland FIN-00029 et, FIN-00029 Helsinki, Finland
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 1-2, volume: 41, anno: 2001,
pagine: 177 - 183
SICI:
1042-8194(200103)41:1-2<177:PGICLL>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN PHOSPHATASE 2A; COMPARATIVE GENOMIC HYBRIDIZATION; MOLECULAR CHARACTERIZATION; PATHOGENIC ROLE; ATM MUTATIONS; 11Q DELETIONS; HETEROZYGOSITY; CANCER; REGION; PROLIFERATION;
Keywords:
chronic lymphocytic leukemia; mantle cell lymphoma; PPP2R1B gene; mutations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Knuutila, S Univ Helsinki, Cent Hosp, Med Genet Lab, POB 400,Haartmaninkatu 3,4th Floor, FIN-00029 Helsinki, Finland Univ Helsinki POB 400,Haartmaninkatu 3,4th Floor Helsinki Finland FIN-00029
Citazione:
Y. Zhu et al., "PPP2R1B gene in chronic lymphocytic leukemias and mantle cell lymphomas", LEUK LYMPH, 41(1-2), 2001, pp. 177-183

Abstract

Deletion of chromosome bands 11q22-q23 is one of the most common structural chromosome alterations in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). The PPP2R1B gene is located very close to the minimal common deletion region of 11q22-q23 in CLL and MCL. Recently, the PPP2R1B gene was found to be mutated in human lung and colon cancers. To evaluate therole of the PPPZR1B gene in the pathogenesis of CLL and MCL. we performed RT-PCR analysis and cDNA sequencing on 10 CLL RNA samples and SSCP analysison 26 CLL and 37 MCL genomic DNA samples. A deletion of exon 3 was Found in one CLL sample. No mutation was detected in the SSCP analysis. To excludethe possibility of large genomic deletions we performed Southern blotting analysis. One MCL sample showed abnormal bands. Our results do not suggest that the PPPZR1B gene has a major pathogenic role in CLL and MCL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:09:33