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Titolo:
Differential effects of damage within the hippocampal region on memory fora natural, nonspatial odor-odor association
Autore:
Alvarez, P; Lipton, PA; Melrose, R; Eichenbaum, H;
Indirizzi:
Boston Univ, Dept Psychol, Lab Cognit Neurobiol, Boston, MA 02215 USA Boston Univ Boston MA USA 02215 ab Cognit Neurobiol, Boston, MA 02215 USA
Titolo Testata:
LEARNING & MEMORY
fascicolo: 2, volume: 8, anno: 2001,
pagine: 79 - 86
SICI:
1072-0502(200103/04)8:2<79:DEODWT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RATS RATTUS-NORVEGICUS; MONKEYS; LESIONS; SYSTEM; DIET; IMPAIRMENT; AMNESIA; HUMANS; CHOICE; CUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Eichenbaum, H Boston Univ, Dept Psychol, Lab Cognit Neurobiol, 64 Cummington St, Boston,MA 02215 USA Boston Univ 64 Cummington St Boston MA USA 02215A 02215 USA
Citazione:
P. Alvarez et al., "Differential effects of damage within the hippocampal region on memory fora natural, nonspatial odor-odor association", LEARN MEM, 8(2), 2001, pp. 79-86

Abstract

Debate continues on whether the role of rodent hippocampus in memory is limited to the spatial domain. Recently, this controversy has been addressed with studies on the social transmission of food preference, an odor-odor association task with no spatial requirements, Multiple reports have concluded that damage to the hippocampal region impairs memory in this task, but there remain questions about the extent of damage essential to produce an impairment. Furthermore, a recent stud! (Burton et al. 2000) found no effect of hippocampal] lesions on memory in this task. We tested animals with complete lesions of the hippocampus (H) lesions of the hippocampus plus subiculum (HS), and lesions of the adjacent, anatomically related cortices of the parahippocampal region (PHR). H lesions produced an impairment on spatial delayed alternation, but not on memory for the social transmission of food preference, whereas HS and PHR lesions produced severe and equivalent impairments on memory for the socially acquired food preference. We discuss possible explanations for the discrepancy with the results of Burton et al. (2000) and conclude that the hippocampus and subiculum together play a critical role in the formation of this form of nonspatial, relational memory.

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Documento generato il 02/04/20 alle ore 19:14:59