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Titolo:
Expressional regulation of angiopoietin-1 and-2 and the tie-1 and-2 receptor tyrosine kinases during cutaneous wound healing: A comparative study of normal and impaired repair
Autore:
Kampfer, H; Pfeilschifter, J; Frank, S;
Indirizzi:
Univ Frankfurt Klinikum, Inst Allgemeine Pharmakol & Toxikol, Zentrum Pharmakol, D-60590 Frankfurt, Germany Univ Frankfurt Klinikum Frankfurt Germany D-60590 590 Frankfurt, Germany
Titolo Testata:
LABORATORY INVESTIGATION
fascicolo: 3, volume: 81, anno: 2001,
pagine: 361 - 373
SICI:
0023-6837(200103)81:3<361:EROAAA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; MOLECULAR-CLONING; OVEREXPRESSING ANGIOPOIETIN-1; VASCULAR ENDOTHELIUM; VESSEL DEVELOPMENT; LEPTIN RECEPTOR; GENE; MICE; ANGIOGENESIS; VEGF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Frank, S Univ Frankfurt Klinikum, Inst Allgemeine Pharmakol & Toxikol, Zentrum Pharmakol, Theodor Stern Kai 7, D-60590 Frankfurt, Germany Univ Frankfurt Klinikum Theodor Stern Kai 7 Frankfurt Germany D-60590
Citazione:
H. Kampfer et al., "Expressional regulation of angiopoietin-1 and-2 and the tie-1 and-2 receptor tyrosine kinases during cutaneous wound healing: A comparative study of normal and impaired repair", LAB INV, 81(3), 2001, pp. 361-373

Abstract

It has become evident that a closely regulated presence of vascular endothelial growth factor (VEGF) and angiopoietin (Ang) factors determines the fate of blood vessel formation during angiogenesis. As angiogenesis is central to a normal wound-healing process, we investigated the regulation of Ang-1 and -2 and the related tyrosine kinase with immunoglobulin and epidermal growth factor homology (Tie)-1 and -2 receptors during normal repair in Balb/c mice and diabetes-impaired wound healing conditions in genetically diabetic (db/db) mice. For both normal and impaired healing conditions, we observed a constitutive expression of Ang-1, which was paralleled by an increase of Ang-2 upon injury. Whereas the observed Ang-2 expression declines fromDay 7 after injury in control mice, diabetic-impaired healing was characterized by still increasing amounts of Ang-2 at these time points. Furthermore, Tie-1 was strongly induced during repair with a prolonged expression in diabetic mice, whereas Tie-2 expression was constitutive during normal repair but completely absent in diabetes-impaired healing. The overexpression of Ang-2 in the presence of markedly reduced VEGF in wounds of diabetic micewas associated with a dramatic decrease in endothelial cell numbers compared with normal healing as assessed by analysis of the endothelium-specific markers CD31 and von Willebrand factor, whereas the lymphatic endothelium remained stable as determined by expression of VEGF receptor-3 (VEGFR-3/Flt-4).

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Documento generato il 10/07/20 alle ore 10:27:57