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Titolo:
RECIPROCAL INHIBITORY PARACRINE PATHWAYS LINK HISTAMINE AND SOMATOSTATIN SECRETION IN THE FUNDUS OF THE STOMACH
Autore:
VUYYURU L; HARRINGTON L; ARIMURA A; SCHUBERT ML;
Indirizzi:
MCGUIRE DEPT VET AFFAIRS MED CTR,DEPT MED,DIV GASTROENTEROL,CODE 111N,1201 BROAD ROCK BLVD RICHMOND VA 23249 MCGUIRE DEPT VET AFFAIRS MED CTR,DEPT MED,DIV GASTROENTEROL RICHMOND VA 23249 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT MED RICHMOND VA 23249 TULANE UNIV,DEPT MED BELLE CHASSE LA 70037
Titolo Testata:
American journal of physiology: Gastrointestinal and liver physiology
fascicolo: 1, volume: 36, anno: 1997,
pagine: 106 - 111
SICI:
0193-1857(1997)36:1<106:RIPPLH>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; PERFUSED RAT STOMACH; MUCOSAL CELLS; ANTRAL SOMATOSTATIN; ENDOCRINE-CELLS; H-3 RECEPTORS; RELEASE; ANTIBODIES;
Keywords:
THIOPERAMIDE; (R)(-)-ALPHA-METHYLHISTAMINE; CHOLINERGIC; ACETYLCHOLINE; GASTRIC ACID SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
L. Vuyyuru et al., "RECIPROCAL INHIBITORY PARACRINE PATHWAYS LINK HISTAMINE AND SOMATOSTATIN SECRETION IN THE FUNDUS OF THE STOMACH", American journal of physiology: Gastrointestinal and liver physiology, 36(1), 1997, pp. 106-111

Abstract

The present study was designed to examine the functional linkage between histamine and somatostatin secretion in the fundus of the stomach. In segments of rat fundic mucosa, superfusion with thioperamide (H-3 antagonist) increased somatostatin and decreased histamine secretion; superfusion with (R)(-)-alpha-methylhistamine (H-3 agonist) had the opposite effect, decreasing somatostatin and increasing histamine secretion. The pattern implied that endogenous histamine, acting via H-3 receptors, exerts an inhibitory paracrine influence on somatostatin secretion. Superfusion with somatostatin antibody (1:250)increased histamine secretion, implying that endogenous somatostatin, in turn, exerts aninhibitory paracrine influence an histamine secretion. Somatastatin antibody also abolished the decrease in histamine secretion induced by thioperamide and the increase:in histamine secretion induced by (R)(-)-alpha-methylhistamine, implying that changes in histamine secretion induced by activation of H-3 receptors reflect changes in somatostatin secretion. Superfusion with the muscarinic agonist methacholine alone and in the presence of either H-3 agonist or H-3 antagonist confirmed the existence of reciprocal inhibitory pathways Linking somatostatin and histamine. We conclude that fundic histamine and somatostatin secretion are linked via reciprocal inhibitory paracrine pathways that serve to amplify the regulatory influence of somatostatin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:18:10