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Titolo:
Preliminary observations on differing psychological effects of conjugated and esterified estrogen treatments
Autore:
Friebely, JS; Shifren, JL; Schiff, I; Regestein, QR;
Indirizzi:
Massachusetts Gen Hosp, Vincent Ob Gyn Serv, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Gyn Serv, Boston, MA 02114 USA Brigham & Womens Hosp, Dept Psychiat, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Psychiat, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF WOMENS HEALTH & GENDER-BASED MEDICINE
fascicolo: 2, volume: 10, anno: 2001,
pagine: 181 - 187
SICI:
1524-6094(200103)10:2<181:POODPE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL WOMEN; BRAIN; MOOD; 17-BETA-ESTRADIOL; DEPRESSION; PROGESTIN; ANDROGEN; BEHAVIOR; FITNESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Schiff, I Massachusetts Gen Hosp, Vincent Ob Gyn Serv, 55 Fruit St,VBK-113, Boston, MA 02114 USA Massachusetts Gen Hosp 55 Fruit St,VBK-113 Boston MAUSA 02114 A
Citazione:
J.S. Friebely et al., "Preliminary observations on differing psychological effects of conjugated and esterified estrogen treatments", J WOMEN H G, 10(2), 2001, pp. 181-187

Abstract

During a double-blind comparison of menopausal replacement therapy with estrogen alone compared with estrogen plus methyltestosterone (meT), subjectswho had been on conjugated equine estrogen (CEE) said they felt better when placed on esterified estrogen (EE). We, therefore, tested whether these estrogen treatments differed in their neuropsychological effects. Subjects were 34 healthy menopausal respondents to advertisements younger than age 66who were on CEE at baseline. Each was randomized into the EE condition, either immediately after baseline or after they first took EE plus added meT for 8 weeks. We compared neuropsychological measures between these two conditions. Data included cognitive performance test results and symptom self-ratings. Multivariate techniques were used to adjust for the effects of treatment order. Compared with prior CEE treatment, EE treatment was associatedwith significantly improved scores on the Zung Self-Rated Depression Scaleand on Switching Attention Test performance. Further investigation is warranted to determine if different forms of estrogen replacement induce different neuropsycholiogical effects.

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Documento generato il 28/01/20 alle ore 21:16:24