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Titolo:
Association between exogenous atrial natriuretic peptide and hemodynamics in dogs with congestive heart failure produced by experimental mitral regurgitation
Autore:
Asano, K; Masuda, K; Okumura, M; Kadosawa, T; Fujinaga, T;
Indirizzi:
Hokkaido Univ, Grad Sch Vet Med, Dept Vet Clin Sci, Lab Vet Surg, Sapporo,Hokkaido 0600018, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600018 poro,Hokkaido 0600018, Japan
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 3, volume: 63, anno: 2001,
pagine: 243 - 250
SICI:
0916-7250(200103)63:3<243:ABEANP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-ALDOSTERONE SYSTEM; LEFT-VENTRICULAR DYSFUNCTION; DILATED CARDIOMYOPATHY; CONSCIOUS DOGS; PLASMA ATRIAL; ACTIVATION; POLYPEPTIDE; DOBUTAMINE; INHIBITION; MECHANISM;
Keywords:
atrial natriuretic peptide; canine; cardiac performance; congestive heart failure; mitral regurgitation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Asano, K Nihon Univ, Coll Bioresource Sci, Dept Vet Med, Lab Vet Surg, Fujisawa, Kanagawa 2528510, Japan Nihon Univ Fujisawa Kanagawa Japan 2528510 nagawa 2528510, Japan
Citazione:
K. Asano et al., "Association between exogenous atrial natriuretic peptide and hemodynamics in dogs with congestive heart failure produced by experimental mitral regurgitation", J VET MED S, 63(3), 2001, pp. 243-250

Abstract

Association between exogenous atrial natriuretic peptide (ANP) and hemodynamic changes was ascertained in 3 dogs with overt congestive heart failure (CHF(+)) and 3 dogs without congestive heart failure (CHF(-)) caused by experimental mitral regurgitation (MR). The hemodynamic measurements were recorded in all dogs during and after 1 hr infusion of ANP at the rate of 0.1 (low dose), 0.5 (medium dose) and 1.0 (high dose) mug/kg/min, respectively. Heart rate, mean arterial pressure, pulmonary capillary wedge pressure (PCWP) and systemic vascular resistance decreased significantly during and after ANP infusion even with low dose in the CHF(+). Stroke volume, stroke volume index and cardiac output in the CHF(+) during and after ANP infusion showed an increasing trend as compared with the CHF(-). Double product, an indicator of myocardial oxygen consumption, significantly decreased during andafter ANP administration at all doses in the CHF(+). These findings indicate that even at low dose, exogenous ANP improves cardiac performance and reduces myocardial oxygen consumption in the CHF(+), and suggest that ANP hasbeneficial effects in the treatment of dogs with overt congestive heart failure resulting from MR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:40:17