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Titolo:
beta 3-adrenergic agonist up-regulates uncoupling proteins 2 and 3 in skeletal muscle of the mouse
Autore:
Nakamura, Y; Nagase, I; Asano, A; Sasaki, N; Yoshida, T; Umekawa, T; Sakane, N; Saito, M;
Indirizzi:
Hokkaido Univ, Sch Vet Med, Dept Biomed Sci, Sapporo, Hokkaido 0600818, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600818 oro, Hokkaido 0600818, Japan Kyoto Prefectural Univ Med, Dept Internal Med 1, Kyoto 602, Japan Kyoto Prefectural Univ Med Kyoto Japan 602 ernal Med 1, Kyoto 602, Japan
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 3, volume: 63, anno: 2001,
pagine: 309 - 314
SICI:
0916-7250(200103)63:3<309:B3AUUP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE ADIPOSE-TISSUE; YELLOW KK MICE; THYROID-HORMONE; MESSENGER-RNA; SELECTIVE AGONISTS; BROWN ADIPOCYTES; FOOD-INTAKE; EXPRESSION; THERMOGENESIS; ANTIOBESITY;
Keywords:
adipose tissue; beta 3-adrenergic agonist; fatty acid; obese mouse; uncoupling protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, Y Hokkaido Univ, Sch Vet Med, Dept Biomed Sci, Sapporo, Hokkaido0600818, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600818 o 0600818, Japan
Citazione:
Y. Nakamura et al., "beta 3-adrenergic agonist up-regulates uncoupling proteins 2 and 3 in skeletal muscle of the mouse", J VET MED S, 63(3), 2001, pp. 309-314

Abstract

Chronic stimulation of the beta3-adrenergic receptor (AR) in obese animalsresulted in a reduced adiposity associated with an increased expression ofthermogenic uncoupling protein (UCP)1 in adipose tissues. In this study, the mRNA expression of newly cloned UCP isoforms (UCP2 and UCP3) were examined in obese yellow KK and C57BL control mice. UCP2 mRNA was found in all tissues examined, with higher levels in adipose tissues and skeletal muscle of the obese mice. UCP3 mRNA was expressed in skeletal muscle, heart and brown adipose tissue similarly in the two mouse strains. Daily injection of a selective beta3-adrenergic agonist, CL316,243 (0.1 mg/kg), for 10 days resulted in a marked reduction of white fat pad weight and 1.8 similar to4.8-fold increase in the mRNA levels of UCP2 and UCP3 in skeletal muscle of obesemice. No noticeable change in the UCP2 and 3 mRNA levels was found in brown and white adipose tissues. It was also found that CL316,243 injection produced a marked and sustained elevation of the plasma free fatty acid level. These results, together with our previous Endings of the fatty acid-induced UCP expression in a myocyte cell line in vitro, suggest that the beta3-ARagonist-induced UCP expression in skeletal muscle may be mediated through the elevated plasma free fatty acids. It was also suggested that anti-obesity effect of beta3-AR agonists is attributable to increased thermogenesis not only by UCP1 but also by UCP2 and UCP3.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:52:19