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Titolo:
Conformational selection of non-hydrolyzable glycomimetics: the conformation of N,N '-diacetylthiochitobiose bound to wheat germ agglutinin
Autore:
Munoz, JL; Garcia-Herrero, A; Asensio, JL; Auzennaeau, FI; Canada, FJ; Jimenez-Barbero, J;
Indirizzi:
CSIC, Inst Quim Organ, E-28006 Madrid, Spain CSIC Madrid Spain E-28006CSIC, Inst Quim Organ, E-28006 Madrid, Spain Pasteur Merieux Connaught, Dept Biochem, N York, ON M2R 3T4, Canada Pasteur Merieux Connaught N York ON Canada M2R 3T4 rk, ON M2R 3T4, Canada
Titolo Testata:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
fascicolo: 8, , anno: 2001,
pagine: 867 - 872
SICI:
1472-7781(2001):8<867:CSONGT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR MECHANICS CALCULATIONS; RICIN-B-CHAIN; C-GLYCOSIDES; NMR-SPECTROSCOPY; BINDING-SITES; FORCE-FIELD; HEVEIN DOMAINS; O-GLYCOSIDES; OLIGOSACCHARIDES; LACTOSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Jimenez-Barbero, J CSIC, Inst Quim Organ, Juan de la Cierva 3, E-28006 Madrid, Spain CSIC Juan de la Cierva 3 Madrid Spain E-28006 d, Spain
Citazione:
J.L. Munoz et al., "Conformational selection of non-hydrolyzable glycomimetics: the conformation of N,N '-diacetylthiochitobiose bound to wheat germ agglutinin", J CHEM S P1, (8), 2001, pp. 867-872

Abstract

The conformational behaviour of N,N'-diacetyl-4-thiochitobiose (1) has been studied using a combination of NMR spectroscopy (NOE data) and molecular mechanics calculations. Analogies and differences with the natural compoundN,N'-diacetylchitobiose (2) have been found. Moreover, the study of its bound conformation to the lectin wheat germ agglutinin has also been studied using TR-NOE experiments. A process of conformational selection is observedand only one of the conformers present in aqueous solution for the free state is bound by the lectin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:43:31