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Titolo:
Towards a modular approach for heparin synthesis
Autore:
Haller, M; Boons, GJ;
Indirizzi:
Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 rbohydrate Res Ctr, Athens, GA 30602 USA
Titolo Testata:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
fascicolo: 8, , anno: 2001,
pagine: 814 - 822
SICI:
1472-7781(2001):8<814:TAMAFH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATENT-ACTIVE GLYCOSYLATION; FIBROBLAST GROWTH-FACTOR; PRIMARY ALCOHOL GROUPS; OLIGOSACCHARIDE SYNTHESIS; VINYL GLYCOSIDES; TRISACCHARIDE LIBRARIES; MEDIATED OXIDATION; CHEMICAL SYNTHESIS; HIGH-AFFINITY; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Boons, GJ Univ Georgia, Complex Carbohydrate Res Ctr, 220 Riverbend Rd, Athens, GA 30602 USA Univ Georgia 220 Riverbend Rd Athens GA USA 30602 , GA 30602 USA
Citazione:
M. Haller e G.J. Boons, "Towards a modular approach for heparin synthesis", J CHEM S P1, (8), 2001, pp. 814-822

Abstract

Trisaccharide 23 and sulfated disaccharide 28 have been prepared by a strategy whereby the glucuronic acid moieties were introduced at a late stage of a synthetic sequence by selective oxidation of primary hydroxy groups with TEMPO and NaOCl. During the oxidation step, the primary hydroxy groups ofglucosamine moieties were efficiently protected as TBDPS ethers. The oxidation procedure and removal of the TBDPS groups proved to be compatible withthe presence of sulfate esters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:26:52