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Titolo:
Suppression of constitutive but not IL-1 beta-inducible expression of monocyte chemoattractant protein-1 in mesangial cells by retinoic acids: Intervention in the activator protein-1 pathway
Autore:
Lucio-Cazana, J; Nakayama, K; Xu, Q; Konta, T; Moreno-Manzano, V; Furusu, A; Kitamura, M;
Indirizzi:
Univ Coll London, Middlesex Hosp, Royal Free & Univ Coll Med Sch, Dept Med,Jules Thorn Inst, London W1T 3AA, England Univ Coll London London England W1T 3AA rn Inst, London W1T 3AA, England Univ Alcala de Henares, Fac Med, Dept Fisiol, Madrid, Spain Univ Alcala deHenares Madrid Spain Fac Med, Dept Fisiol, Madrid, Spain
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 4, volume: 12, anno: 2001,
pagine: 688 - 694
SICI:
1046-6673(200104)12:4<688:SOCBNI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; GENE-EXPRESSION; C-JUN; MATRIX METALLOPROTEINASE-1; ENDOTHELIAL-CELLS; GLOMERULAR CELLS; MCP-1 EXPRESSION; GROWTH-FACTOR; IN-VIVO; AP-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Kitamura, M Univ Coll London, Middlesex Hosp, Royal Free & Univ Coll Med Sch, Dept Med,Jules Thorn Inst, 7th Floor,Mortimer St, London W1T 3AA, England Univ Coll London 7th Floor,Mortimer St London England W1T 3AA
Citazione:
J. Lucio-Cazana et al., "Suppression of constitutive but not IL-1 beta-inducible expression of monocyte chemoattractant protein-1 in mesangial cells by retinoic acids: Intervention in the activator protein-1 pathway", J AM S NEPH, 12(4), 2001, pp. 688-694

Abstract

Retinoic acid regulates a wide range of biologic processes, including inflammation. This study investigated the effect of all-trans-retinoic acid (t-RA) on the constitutive and cytokine-inducible expression of monocyte chemoattractant protein 1 (MCP-1) in rat mesangial cells. Serum-deprived mesangial cells exhibited substantial levels of MCP-1 mRNA, and the expression wasmarkedly upregulated by interleukin-1 beta (IL-1 beta). Pretreatment with t-RA abrogated the constitutive mRNA expression but did not inhibit the IL-1 beta -inducible expression. The similar effects were observed by 9-cis-RA. The suppressive effect of t-RA required retinoic acid receptors. t-RA didnot affect the stability of MCP-1 mRNA, indicating that its suppressive effect was at the transcriptional level. Experiments that used pharmacologic and genetic inhibitors showed that the IL-1 beta -inducible MCP-1 expression was dependent on nuclear factor-kappaB (NF-kappaB) and independent of activator protein 1 (AP-1). In contrast, the constitutive expression of MCP-1 was dependent on both NF-kappaB and AP-1. t-RA substantially inhibited the constitutive activity of AP-1 but did not inhibit NF-kappaB activity in mesangial cells. These data suggested that (1) constitutive and IL-1 beta -inducible expression of MCP-1 was differently regulated by AP-1 and NF-kappaB and (2) t-RA inhibited selectively the constitutive expression of MCP-1 viaintervention in the AP-1 pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:19:00