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Titolo:
Activation of the cardiac renin-angiotensin system and increased myocardial collagen expression in human aortic valve disease
Autore:
Fielitz, J; Hein, S; Mitrovic, V; Pregla, R; Zurbrugg, HR; Warnecke, C; Schaper, J; Fleck, E; Regitz-Zagrosek, V;
Indirizzi:
Deutesch Herzzentrum Berlin, D-13353 Berlin, Germany Deutesch Herzzentrum Berlin Berlin Germany D-13353 13353 Berlin, Germany Humboldt Univ, Campus Virchow Klinikum, Charite, Berlin, Germany Humboldt Univ Berlin Germany Virchow Klinikum, Charite, Berlin, Germany Kerckhoff Klin, Abt Herz Gefass & Thoraxchirurg, Bad Nauheim, Germany Kerckhoff Klin Bad Nauheim Germany Thoraxchirurg, Bad Nauheim, Germany DHZB, Klin Herz Gefass & Thoraxchirurg, Berlin, Germany DHZB Berlin Germany , Klin Herz Gefass & Thoraxchirurg, Berlin, Germany MPI Expt Kardiol, Bad Nauheim, Germany MPI Expt Kardiol Bad Nauheim Germany Expt Kardiol, Bad Nauheim, Germany
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 5, volume: 37, anno: 2001,
pagine: 1443 - 1449
SICI:
0735-1097(200104)37:5<1443:AOTCRS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFORMING GROWTH FACTOR-BETA(1); RECEPTOR-TYPE-1 MESSENGER-RNA; LEFT-VENTRICULAR HYPERTROPHY; EXTRACELLULAR-MATRIX COMPONENTS; CONVERTING ENZYME-INHIBITION; FAILING HUMAN HEART; PRESSURE-OVERLOAD; GENE-EXPRESSION; DILATED CARDIOMYOPATHY; HYPERTENSIVE RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Regitz-Zagrosek, V Deutesch Herzzentrum Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany Deutesch Herzzentrum Berlin Augustenburger Pl 1 Berlin Germany D-13353
Citazione:
J. Fielitz et al., "Activation of the cardiac renin-angiotensin system and increased myocardial collagen expression in human aortic valve disease", J AM COL C, 37(5), 2001, pp. 1443-1449

Abstract

OBJECTIVES We sought to determine whether the cardiac renin-angiotensin system (RAS) is activated in human aortic valve disease depending on left ventricular function, and We analyzed the concomitant regulation of the extracellular matrix components. BACKGROUND In animal models with pressure or volume load, activation of the cardiac RAS increases fibrosis. In human aortic valve disease, the ventricular collagen protein content is increased, but only scarce data on the activation state of time cardiac RAS and its effects on collagen and fibronectin messenger ribonucleic acid (mRNA) are available. METHODS In left ventricular biopsies from patients with aortic valve stenosis (AS) and aortic valve regurgitation and from control subjects, we quantitated mRNAs for angiotensin-converting enzyme (ACE), chymase, transforminggrowth factor-beta, (TGF-beta(1)), collagen I, collagen III and fibronectin by reverse-transcription polymerase chain reaction. RESULTS Proteins were localized by immunohistochemistry; ACE activity was determined by high performance liquid chromatography; and TGF-beta protein by quantitative enzyme immunoassay. Protein, ACE and TGF-beta(1) mRNA were significantly increased in patients with AS and AR (1.5- to 2.1-fold) and correlated with each other. The increase occurred also in patients with normal systolic function. Collagen I and III and fibronectin mRNAs were both upregulated about twofold in patients with AS and AR. In AS, collagen and fibronectin mRNA expression levels were positively correlated with left ventricular end-diastolic pressure and inversely with left ventricular ejection fraction (LVEF). CONCLUSION In human hearts, pressure and volume overload increases cardiacACE and TGF-beta, in the early stages. This activation of the cardiac RAS may contribute to the observed increase in collagen I and III and fibronectin mRNA expression. The increase in extracellular matrix already exists in patients with a normal LVEF, and it increases with functional impairment. aAm Coil Cardiol 2001;37:1143-9) (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:14:49