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Titolo:
Physiologic assessment of coronary artery stenosis by coronary flow reserve measurements with transthoracic Doppler echocardiography: Comparison withexercise thallium-201 single-photon emission computed tomography
Autore:
Daimon, M; Watanabe, H; Yamagishi, H; Muro, T; Akioka, K; Hirata, K; Takeuchi, K; Yoshikawa, J;
Indirizzi:
Osaka City Univ, Grad Sch Med, Dept Internal Med & Cardiol, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 diol, Abeno Ku, Osaka 5458585, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 5, volume: 37, anno: 2001,
pagine: 1310 - 1315
SICI:
0735-1097(200104)37:5<1310:PAOCAS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUIDE-WIRE; MYOCARDIAL PERFUSION; VELOCITY RESERVE; BLOOD-FLOW; NONINVASIVE ASSESSMENT; DISEASE; PREDICT; DISTAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Watanabe, H Osaka City Univ, Grad Sch Med, Dept Internal Med & Cardiol, Abeno Ku, 1-4-3 Asahimachi, Osaka 5458585, Japan Osaka City Univ 1-4-3 Asahimachi Osaka Japan 5458585 5, Japan
Citazione:
M. Daimon et al., "Physiologic assessment of coronary artery stenosis by coronary flow reserve measurements with transthoracic Doppler echocardiography: Comparison withexercise thallium-201 single-photon emission computed tomography", J AM COL C, 37(5), 2001, pp. 1310-1315

Abstract

OBJECTIVES We evaluated the value of coronary flow reserve (CFR), as determined by transthoracic Doppler echocardiography (TTDE), for physiologic assessment of coronary artery stenosis severity, and we compared (TTDE measurements with those obtained by exercise thallium-201 (Tl-201) single-photon emission computed tomography (SPECT). BACKGROUND Coronary flow reserve measurements by TTDE have been reported to he useful for assessing angiographic left anterior descending coronary artery (LAD) stenosis. However, discrepancies exist between angiographic and physiologic estimates of coronary lesion severity. METHODS We studied 36 patients suspected of having coronary artery disease. The flow velocity in the distal LAD was measured by TTDE both at rest andduring intravenous infusion of adenosine. Coronary flow reserve was calculated as the ratio of hyperemic to basal peak (peak CFR) and mean (mean CFR)diastolic flow velocities. The CFR measurements by TTDE were compared withthe results of TI-201-SPECT. RESULTS Complete TTDE data were acquired for 33 of 36 study patients. Of these 33 patients, TI-201-SPECT confirmed reversible perfusion defects in the LAD territories in 12 patients (group A). Twenty-one patients had normal perfusion in the LAD territories (group B). Peak CFR and mean CFR (mean value +/- SD) were 1.5 +/- 0.6 and 1.5 +/- 0.7 in group A and 2.8 +/- 0.8 and 2.7 +/- 0.7 in group B, respectively. Both peak and mean CFR less than or equal to2.0 predicted reversible perfusion defects, with a sensitivity and specificity of 92% and 90%, respectively. CONCLUSIONS Noninvasive measurement of CFR by TTDE provides data equivalent to those obtained by TI-201-SPECT for physiologic estimation of the severity of LAD stenosis. (J Am Coil Cardiol 2001;37:1310-5) (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:49:25