Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A genetic analysis of the Epworth Sleepiness Scale in 1560 World War II male veteran twins in the NAS-NRC Twin Registry
Autore:
Carmelli, D; Bliwise, DL; Swan, GE; Reed, T;
Indirizzi:
SRI Int, Ctr Hlth Sci, Menlo Park, CA 94025 USA SRI Int Menlo Park CA USA94025 t, Ctr Hlth Sci, Menlo Park, CA 94025 USA Emory Univ, Med Ctr, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 mory Univ, Med Ctr, Atlanta, GA 30322 USA Indiana Univ, Indianapolis, IN 46204 USA Indiana Univ Indianapolis IN USA46204 a Univ, Indianapolis, IN 46204 USA
Titolo Testata:
JOURNAL OF SLEEP RESEARCH
fascicolo: 1, volume: 10, anno: 2001,
pagine: 53 - 58
SICI:
0962-1105(200103)10:1<53:AGAOTE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DAYTIME SLEEPINESS; FAMILIAL AGGREGATION; APNEA; DISTURBANCES; NARCOLEPSY; DISORDER; PATTERNS; HEALTH;
Keywords:
daytime sleepiness; elderly; genetic; twins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Carmelli, D SRI Int, Ctr Hlth Sci, 333 Ravenswood Ave, Menlo Park, CA 94025 USA SRI Int 333 Ravenswood Ave Menlo Park CA USA 94025 A 94025 USA
Citazione:
D. Carmelli et al., "A genetic analysis of the Epworth Sleepiness Scale in 1560 World War II male veteran twins in the NAS-NRC Twin Registry", J SLEEP RES, 10(1), 2001, pp. 53-58

Abstract

Responses to the eight-item Epworth Sleepiness Scale (ESS) obtained from 1560 World War II male veteran twin pairs [818 monozygotic (MZ), 742 dizygotic (DZ)] were analysed to determine the extent to which genetic influences are involved in self-reported daytime sleepiness in the elderly. Average ESS score (+/- SD) in this sample was 7.1 +/- 3.9, range 0-24. More than halfof the twins (65%-67%) reported a moderate to high chance of falling asleep while lying down to rest; fewer than 3% admitted that this would occur while sitting and talking to someone or while stopped in traffic. Daytime sleepiness was not associated with age but was significantly and positively associated with obesity. The intraclass twin correlation on ESS scores was 0.39 in MZ pairs and 0.21 in DZ pairs (both P < 0.001). Structural equation modeling of the observed variance-covariance matrices for MZ and DZ twins estimated the heritability of ESS to be 38% (95% confidence interval 33%-44%). Environmental influences not shared by twin brothers accounted for the remaining variance in daytime sleepiness. A reasonable interpretation of the heritability of ESS in this healthy cohort of elderly male twins is a genetic susceptibility for disordered breathing during sleep.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:45:42