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Titolo:
Ion exchange chromatographic determination of olpadronate, phosphate, phosphite, chloride and methanesulfonic acid
Autore:
Quattrocchi, O; Frisardi, L; Iglesias, M; Noya, M; Caputto, M; Ferraris, D; Siliprandi, D; Piccinni, E;
Indirizzi:
Gador SA, Analyt Dev Dept, RA-1428 Buenos Aires, DF, Argentina Gador SA Buenos Aires DF Argentina RA-1428 28 Buenos Aires, DF, Argentina
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 5-6, volume: 24, anno: 2001,
pagine: 1011 - 1018
SICI:
0731-7085(200103)24:5-6<1011:IECDOO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; AUTOMATED PRECOLUMN DERIVATIZATION; PHARMACEUTICAL DOSAGE FORMULATIONS; FLUORESCENCE DETECTION; ALENDRONATE; URINE; BISPHOSPHONATES; PAMIDRONATE; FORMS; DISODIUM;
Keywords:
olpadronate; bisphosphonate analysis; impurities; HPLC; ion chromatography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Quattrocchi, O Gador SA, Analyt Dev Dept, Cramer 2462, RA-1428 Buenos Aires, DF, Argentina Gador SA Cramer 2462 Buenos Aires DF Argentina RA-1428 tina
Citazione:
O. Quattrocchi et al., "Ion exchange chromatographic determination of olpadronate, phosphate, phosphite, chloride and methanesulfonic acid", J PHARM B, 24(5-6), 2001, pp. 1011-1018

Abstract

A method based on single column ion chromatography with UV detection was developed for purity testing and assay of monosodium olpadronate. The analyte aqueous solution is precipitated with methanol to enhance the impurities/olpadronate molar ratio, thus improving purity determination at trace levels. The resulting solution is injected into a standard chromatographic system with UV detector in indirect mode with a Waters IC Pak HR column using diluted nitric acid as the moblie phase. The method was fully validated according to ICH guidelines for the determination of phosphite, phosphate, chloride and methanesulfonic acid in olpadronate bring suitable for purity testing and assay. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:52:52