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Titolo:
Ultrastructural deficiency in autonomic innervation in cremasteric muscle of boys with undescended testis
Autore:
Tanyel, FC; Muftuoglu, S; Dagdeviren, A; Karakoc, L; Buyukpamukcu, N;
Indirizzi:
Hacettepe Univ, Fac Med, Dept Pediat Surg, TR-06100 Ankara, Turkey Hacettepe Univ Ankara Turkey TR-06100 diat Surg, TR-06100 Ankara, Turkey Hacettepe Univ, Fac Med, Dept Histol Embryol, TR-06100 Ankara, Turkey Hacettepe Univ Ankara Turkey TR-06100 l Embryol, TR-06100 Ankara, Turkey
Titolo Testata:
JOURNAL OF PEDIATRIC SURGERY
fascicolo: 4, volume: 36, anno: 2001,
pagine: 573 - 578
SICI:
0022-3468(200104)36:4<573:UDIAII>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTICULAR DESCENT; GENITOFEMORAL NERVE; PROCESSUS-VAGINALIS; INGUINAL-HERNIA; CELL-DEATH; MORPHOLOGY; CHILDREN; NEURONS; GANGLIA; RAT;
Keywords:
electron microscopy; cremaster muscle; cryptorchidism; autonomic nervous system; androgen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Tanyel, FC Univ Hacettepe, Childrens Hosp, Dept Pediat Surg, TR-06100 Ankara, Turkey Univ Hacettepe Ankara Turkey TR-06100 TR-06100 Ankara, Turkey
Citazione:
F.C. Tanyel et al., "Ultrastructural deficiency in autonomic innervation in cremasteric muscle of boys with undescended testis", J PED SURG, 36(4), 2001, pp. 573-578

Abstract

Background/Purpose: The cremaster muscles (CM) associated with undescendedtestis reveal neurogenic alterations that mainly affect type 2 fibers. Theultrastructure of CM has been evaluated to define if further evidence to explain the alterations could be identified. Methods: CM of 8 boys with inguinal hernia and 8 boys with undescended testis at similar ages were biopsied. Samples were processed for electron microscopic evaluations. Semithin and thin sections were examined under an electron microscope. Results: The CM associated with inguinal hernia showed normal ultrastructure. However, some alterations were encountered in CM associated with undescended testis. Unmyelinated fibers were diminished in number, and myelinatedfibers were outnumbering the unmyelinated fibers. Marked disorientation ofmyofibers, redundant sarcolemma, empty sleeves of basal lamina, disarray of myofibrils, densely packed myofilaments, Z disk streaming, dilated sarcoplasmic reticulum, and dense-irregularly shaped mitochondria were repeatedlyencountered. Satellite cells appeared inactive. Most of the fibers were contracted. Conclusions: The decrease in number of unmyelinated fibers appears to represent a decrease in autonomic nerve fibers. The alterations within muscle fibers may reflect a deficiency in autonomic innervation. Autonomic nervous system is highly responsive to circulating androgens. Factors decreasing the vulnerability of autonomic nervous system against androgenic effects may result in a CM with neurogenic alterations, thus inhibiting testicular descent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:21:14