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Titolo:
Residual intestinal disease after milk allergy in infancy
Autore:
Kokkonen, J; Tikkanen, S; Savilahti, E;
Indirizzi:
Univ Hosp Oulu, Dept Pediat, Oulu, Finland Univ Hosp Oulu Oulu FinlandUniv Hosp Oulu, Dept Pediat, Oulu, Finland Helsinki Univ Hosp, Dept Pediat, FIN-00170 Helsinki, Finland Helsinki UnivHosp Helsinki Finland FIN-00170 IN-00170 Helsinki, Finland
Titolo Testata:
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
fascicolo: 2, volume: 32, anno: 2001,
pagine: 156 - 161
SICI:
0277-2116(200102)32:2<156:RIDAMA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-HISTORY; FOOD ALLERGY; LYMPHONODULAR HYPERPLASIA; CHILDREN; HYPERSENSITIVITY; INTOLERANCE; ADULTS; MANIFESTATIONS; SYMPTOMS;
Keywords:
cow's milk allergy; lactose intolerance; IgA-class antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kokkonen, J Oulu Univ, Dept Pediat, FIN-90220 Oulu, Finland Oulu Univ Oulu Finland FIN-90220 at, FIN-90220 Oulu, Finland
Citazione:
J. Kokkonen et al., "Residual intestinal disease after milk allergy in infancy", J PED GASTR, 32(2), 2001, pp. 156-161

Abstract

Background: The subsidence of cow's milk allergy (CMA) has been a subject of controversy. In this study the authors examined whether children with this condition in infancy developed full tolerance or whether they continue to have vague gastrointestinal (GI) symptoms relating to the consumption of milk or dairy products and/or signs of mucosal lesion in the GI tract. Methods: The authors reexamined 56 10-year-old subjects who manifested CMAbefore 1 year of age, and compared the results with a group of 204 randomly selected age-matched school children. Fifty-three and 90 subjects respectively attended a reexamination and were evaluated for growth, lactose tolerance, and immunoglobulin A (IgA)- and IgG-class antibodies to whole cow's milk. The subjects reporting milk-related GI symptoms were encouraged to do a 4-week blind elimination-challenge test with 1 week of low-lactose milli flour. Sixteen of the 25 children were able to complete the trial. Results: Approximately half the study subjects (45%) reported milk-relatedGI symptoms, whereas the respective figure among the control subjects was 10%. Three of six study subjects and seven of 10 control subjects, althoughcompleting the challenge, responded with intestinal symptoms. The growth of the former CMA subjects was retarded compared with the control subjects, and the difference in height was most striking in those subjects still reporting milk-related GI symptoms. However, all subjects had normal hemoglobinand whole-blood folic acid levels. The CMA subjects had significantly (P =0.014) lower concentrations of milk antibodies compared with the control subjects. Lactose malabsorption, defined as high counts in a hydrogen breathtest and related clinical symptoms. was found in eight CMA subjects (14%) and six control subjects (3%). Conclusions: In a certain proportion of subjects with CMA in infancy, GI intolerance seems to persist even after small-dose tolerance has been achieved. The intestinal symptoms and the increased prevalence of lactose intolerance may be caused by a disturbance of the surface epithelial cells-a stateto which the authors refer as,residual intestinal disease.

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Documento generato il 22/09/20 alle ore 23:43:43