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Titolo:
RECOGNITION OF GP43 TUMOR-ASSOCIATED ANTIGEN PEPTIDE BY BOTH HLA-A2 RESTRICTED CTL LINES AND ANTIBODIES FROM MELANOMA PATIENTS
Autore:
TAKAHASHI T; IRIE RF; MORTON DL; HOON DSB;
Indirizzi:
JOHN WAYNE CANC INST,DEPT MOL ONCOL,2200 SANTA MONICA BLVD SANTA MONICA CA 90404 JOHN WAYNE CANC INST,DEPT MOL ONCOL SANTA MONICA CA 90404 JOHN WAYNE CANC INST,DEPT BIOTECHNOL SCI SANTA MONICA CA 90404
Titolo Testata:
Cellular immunology
fascicolo: 2, volume: 178, anno: 1997,
pagine: 162 - 171
SICI:
0008-8749(1997)178:2<162:ROGTAP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MONOCLONAL-ANTIBODY; CYTOLYTIC T-LYMPHOCYTES; TYR-GLN-ILE; ALANINE-PROLINE; GANGLIOSIDE GM2; EPITOPES; INDUCTION; IDENTIFICATION; SEQUENCE; VACCINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
T. Takahashi et al., "RECOGNITION OF GP43 TUMOR-ASSOCIATED ANTIGEN PEPTIDE BY BOTH HLA-A2 RESTRICTED CTL LINES AND ANTIBODIES FROM MELANOMA PATIENTS", Cellular immunology, 178(2), 1997, pp. 162-171

Abstract

Previously, we detected a 43-kDa tumor-associated antigen (TAA) usingthe human monoclonal antibody L92, which recognizes the tetramer peptide KYQI. In the present study, cell lines of cytotoxic T lymphocytes (CTL) specific to the gp43 peptide (DLTMKYQIF) were established from peripheral blood lymphocytes (PBL) of melanoma patients. Patients' PBL (n = 326) of different HLA Class I types were assessed for gp43 CTL activity. CTL specific to gp43 peptide were generated only from HLA-A2 melanoma patients and not normal donors. gp3 CTL recognized gp43 peptide-pulsed autologous BLC and T2 HLA-A2 target cell lines. Furthermore, CTL lines were shown to kill both HLA-A2 autologous and HLA-A2 allogeneic melanoma cell lines, indicating that gp43 peptide can be processedendogenously and presented by melanoma cells as a common TAA. The gp43 CTL lines did not kill normal cells. Specific amino acids of the peptide were shown to be important determinants in stimulation and recognition of CTL. gp43 peptide, recognized by both antibodies and T cells of melanoma patients, is a novel TAA peptide that may play an important role in anti-tumor immunity in human. (C) 1997 Academic Press.

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Documento generato il 25/11/20 alle ore 01:35:32