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Titolo:
Angiographic evaluation of middle cerebral artery reperfusion caused by platelet glycoprotein IIb/IIIa receptor complex antagonist murine 7E3 F(ab ')(2) in a model of focal cerebral ischemia in rats
Autore:
Yang, Y; Li, Q; Nakada, MT; Yang, T; Shuaib, A;
Indirizzi:
Univ Alberta Hosp, Div Neurol, Acute Stroke Program, Edmonton, AB T6G 2B7,Canada Univ Alberta Hosp Edmonton AB Canada T6G 2B7 Edmonton, AB T6G 2B7,Canada Centocor Inc, Malvern, PA 19355 USA Centocor Inc Malvern PA USA 19355Centocor Inc, Malvern, PA 19355 USA
Titolo Testata:
JOURNAL OF NEUROSURGERY
fascicolo: 4, volume: 94, anno: 2001,
pagine: 582 - 588
SICI:
0022-3085(200104)94:4<582:AEOMCA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE-PLASMINOGEN ACTIVATOR; ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY; THROMBOLYTIC THERAPY; THROMBOTIC OCCLUSION; BOLUS INJECTION; STROKE; RESTORATION; INHIBITOR; ANTIBODY;
Keywords:
glycoprotein IIb/IIIa receptor complex antagonist cerebral ischemia; thrombolysis; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Shuaib, A Univ Alberta, Walter Mackenzie Hlth Sci Ctr 2E3 13, Dept Med, Div Neurol, Edmonton, AB T6G 2B7, Canada Univ Alberta Edmonton AB Canada T6G2B7 ton, AB T6G 2B7, Canada
Citazione:
Y. Yang et al., "Angiographic evaluation of middle cerebral artery reperfusion caused by platelet glycoprotein IIb/IIIa receptor complex antagonist murine 7E3 F(ab ')(2) in a model of focal cerebral ischemia in rats", J NEUROSURG, 94(4), 2001, pp. 582-588

Abstract

Object. Antagonists of the glycoprotein IIb/IIIa (GPIIb/IIIa) receptor complex are currently used for the treatment of acute coronary syndromes. The platelet GPIIb/IIIa mediates platelet aggregation, and blocking this receptor complex can reduce or prevent arterial thrombosis. To study the recanalization efficacy of a GPIIb/IIIa antagonist in treating cerebral ischemia, we investigated the therapeutic effects of murine 7E3 F(ab')(2) in a focal embolic cerebral ischemia model in rats. Methods. Focal cerebral ischemia was produced by introducing an autologousthrombus into the right side of the middle cerebral artery (MCA). Thirty male Wistar rats were randomly divided into three groups of 10 rats each: control, 7E3 F(ab'), administered 1 hour postischemia, and 7E3 F(ab'), administered 3 hours postischemia. Animals in the therapeutic groups received intravenous infusion of 6 mg/kg 7E3 F(ab'), at 1 or 3 hours following cerebralembolization. Brain infarct volume, neurobehavioral scores, duration of bleeding, and findings on angiograms of the MCA (before and after infusion) were assessed in all animals. Angiographic evaluation revealed full MCA recanalization in three of 10 animals in each 7E3 F(ab')(2) treatment group. Animals in these groups exhibited a significant reduction in infarct volume when compared with animals inthe control group: 1) infarct volume 1 hour postischemia, 22 +/- 13.9% (p = 0.005); 2) infarct volume 3 hours postischemia, 22.1 +/- 14.8% (p = 0.008); and 3) infarct volume in control animals, 42.4 +/- 16%. Postischemia treatment with 7E3 F(ab'), also improved the animal's neurobehavioral performance. The duration of bleeding significantly increased by more than two times, but there was no associated increase in intracerebral hemorrhage in any group. Conclusions. On the basis of their findings, the authors conclude that murine 7E3 F(ab'), is a potent and safe anti-platelet agent in this experimental focal embolic cerebral ischemia model. Neuronal lesions were significantly reduced when the treatment was delayed up to 3 hours.

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Documento generato il 24/01/20 alle ore 15:39:41