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Titolo:
Decreased expression of c-myc family genes in thymuses from myasthenia gravis patients
Autore:
Nagata, T; Onodera, H; Ohuchi, M; Suzuki, Y; Tago, H; Fujihara, K; Ishii, N; Sugamura, K; Shoji, Y; Handa, M; Tabayashi, K; Itoyama, Y;
Indirizzi:
Tohoku Univ, Sch Med, Dept Neurol, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Sendai Natl Hosp, Div Thorac & Cardiovasc Surg, Sendai, Miyagi 9830045, Japan Sendai Natl Hosp Sendai Miyagi Japan 9830045 endai, Miyagi 9830045, Japan Tohoku Univ, Sch Med, Dept Immunol, Aoba Ku, Sendai, Miyagi 9808574, JapanTohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ, Sch Med, Dept Thorac & Cardiovasc Surg, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1-2, volume: 115, anno: 2001,
pagine: 199 - 202
SICI:
0165-5728(20010402)115:1-2<199:DEOCFG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BCL-2 PROTEIN; CELL-GROWTH; THYMOCYTES;
Keywords:
apoptosis; c-myc; myasthenia gravis; STAM; NFkappaB; thymus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Onodera, H Tohoku Univ, Sch Med, Dept Neurol, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryo Machi Sendai Miyagi Japan 9808574 Japan
Citazione:
T. Nagata et al., "Decreased expression of c-myc family genes in thymuses from myasthenia gravis patients", J NEUROIMM, 115(1-2), 2001, pp. 199-202

Abstract

The thymus is a critical organ for the elimination of autoreactive T cellsby apoptosis. We studied the expression of apoptosis-associated genes, bcl-xL, bad, caspase-3, and c-myc family genes in myasthenia gravis (MG) thymuses. We observed that the mRNA levels of myc family genes, c-myc and max, were markedly reduced in MG thymuses. These results indicate that c-myc-mediated signaling is abnormal in MG thymuses. The levels of molecules whose expressions are associated with myc, such as STAM, prothymosin-alpha, and NFkappaB, were also analyzed. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:40:37