Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Presentation by myoblasts of an epitope from endogenous acetylcholine receptor indicates a potential role in the spreading of the immune response
Autore:
Curnow, J; Corlett, L; Willcox, N; Vincent, A;
Indirizzi:
Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Neurosci Grp, Oxford OX3 9DS, England Univ Oxford Oxford England OX3 9DS Neurosci Grp, Oxford OX3 9DS, England
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1-2, volume: 115, anno: 2001,
pagine: 127 - 134
SICI:
0165-5728(20010402)115:1-2<127:PBMOAE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN-PRESENTING CELLS; CD4(+) T-CELLS; MYASTHENIA-GRAVIS; ENDOTHELIAL-CELLS; INTERFERON-GAMMA; MUSCLE-CELLS; EXPRESSION; INDUCTION; COMPLEX; LINE;
Keywords:
acetylcholine receptor; endogenous antigen presentation; myoblast; MHC; myasthenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Vincent, A Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Neurosci Grp, Oxford OX3 9DS, England Univ Oxford Oxford England OX3 9DS p, Oxford OX3 9DS, England
Citazione:
J. Curnow et al., "Presentation by myoblasts of an epitope from endogenous acetylcholine receptor indicates a potential role in the spreading of the immune response", J NEUROIMM, 115(1-2), 2001, pp. 127-134

Abstract

It is generally considered that myoblasts are unable to prime naive T cellresponses without help from professional antigen-presenting cells (APC). However. their ability to present endogenous antigens to previously primed Tlymphocytes in the secondary phase of a T cell response has not been well studied. We show here that primary human myoblasts, when stimulated with IFN gamma to express class IT MHC, can present an endogenous epitope, probably an acetylcholine receptor (AChR) peptide, to a CD4(+) AChR-specific T helper lymphocyte clone. Presentation leads to secretion of IFN gamma by the Tcell clone and, in addition, killing of the myoblast. Our results suggest that, during the effector phase of the immune response, myoblasts could enhance the inflammatory response by presenting endogenous antigen, and thereby become targets for CD4(+) T lymphocyte-induced cytotoxicity; subsequent release of myoblast antigens could then lead to inter- and intra-molecular determinant spreading. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 02:05:32