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Titolo:
Protective effect of 7-nitroindazole against DSP-4 induced noradrenaline depletion in mouse hippocampus
Autore:
Szoko, E; Haberle, D; Halasz, AS; Tekes, K; Magyar, K;
Indirizzi:
Semmelweis Univ Med, Dept Pharmacodynam, H-1089 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1089 am, H-1089 Budapest, Hungary
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 4, volume: 108, anno: 2001,
pagine: 407 - 413
SICI:
0300-9564(2001)108:4<407:PEO7AD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; MONOAMINE-OXIDASE; INHIBITOR 7-NITROINDAZOLE; INDUCED NEUROTOXICITY; 7-NITRO INDAZOLE; IN-VIVO; MAO-B; NEURONS; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; RELEASE;
Keywords:
7-nitroindazole; DSP-4; neuroprotection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Szoko, E Semmelweis Univ Med, Dept Pharmacodynam, Nagyvarad Ter 4, H-1089 Budapest,Hungary Semmelweis Univ Med Nagyvarad Ter 4 Budapest Hungary H-1089 gary
Citazione:
E. Szoko et al., "Protective effect of 7-nitroindazole against DSP-4 induced noradrenaline depletion in mouse hippocampus", J NEURAL TR, 108(4), 2001, pp. 407-413

Abstract

N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) is a selective noradrenaline (NA) uptake blocker, capable of inducing a longlasting depletion ofNA in some noradrenergic axon terminals originating from the locus coeruleus in rodents. Pretreatment with 7-nitroindazole, a fairly selective inhibitor of neuronal nitric oxide synthase in vivo, partially prevented DSP-4 induced NA depletion in mouse hippocampus measured seven days after the neurotoxic insult. Administration of L-arginine, the substrate of nitric oxide synthase, altered neither the NA depletion induced by DSP-4, nor the protective effect of 7-nitroindazole. Inhibition of nitric oxide synthesis by N(G)-nitro-L-arginine methyl ester did not attenuate the NA depleting effect ofDSP-LC. Thus, the contribution of neuronal nitric oxide synthase inhibition to the protective effect of 7-nitroindazole needs further studies. As 7-nitroindazole did not block NA uptake, this cannot play a part in the protective effect. The possible contribution of monoamine oxidase B enzyme inhibition by 7-nitroindazole to the protective effect is also discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:29:01