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Titolo:
Distribution of hepatitis C virus infection in liver biopsies from children and adults with chronic hepatitis C
Autore:
de Lucas, S; Bartolome, J; Rodriguez-Inigo, E; Casqueiro, M; Millan, A; Ruiz-Moreno, M; Oliva, H; Carreno, V;
Indirizzi:
Fdn Estudio Hepatitis Virales, Madrid 28015, Spain Fdn Estudio Hepatitis Virales Madrid Spain 28015 es, Madrid 28015, Spain Hosp Pardo Aravaca, Inst Hepatol, Madrid, Spain Hosp Pardo Aravaca Madrid Spain do Aravaca, Inst Hepatol, Madrid, Spain Fdn Jimenez Diaz, Dept Pediat, E-28040 Madrid, Spain Fdn Jimenez Diaz Madrid Spain E-28040 Dept Pediat, E-28040 Madrid, Spain Fdn Jimenez Diaz, Dept Pathol, E-28040 Madrid, Spain Fdn Jimenez Diaz Madrid Spain E-28040 Dept Pathol, E-28040 Madrid, Spain
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 1, volume: 64, anno: 2001,
pagine: 1 - 5
SICI:
0146-6615(200105)64:1<1:DOHCVI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; RNA LEVELS; INJURY;
Keywords:
in situ hybridization; histological damage; HCV viral load;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Carreno, V Fdn Estudio Hepatitis Virales, C Guzman el Bueno 72, Madrid 28015, Spain Fdn Estudio Hepatitis Virales C Guzman el Bueno 72 Madrid Spain 28015
Citazione:
S. de Lucas et al., "Distribution of hepatitis C virus infection in liver biopsies from children and adults with chronic hepatitis C", J MED VIROL, 64(1), 2001, pp. 1-5

Abstract

Chronic hepatitis C in children is characterized by milderforms of liver damage than those found in adults. Such a difference has been attributed to a low viral load in children that may lead to poor recognition of infected cells by the immune system. One approach that could be used to confirm thishypothesis may be to examine the number of infected hepatocytes in liver biopsies. Paraffin embedded liver biopsies from 21 children and 15 adults with chronic hepatitis C virus (HCV) infection (with a similar duration of the infection) were hybridized in situ and the percentage of infected hepatocytes was correlated with the histological activity index, alanine aminotransferase levels and HCV viraemia levels. Histological activity index and HCVviraemia levels were statistically higher (P<0.05 and P<0.01 respectively)in adults than in children, and the percentage of infected hepatocytes washigher in adults (11.0 +/- 19.7%) than in children (4.6 +/- 3.6%), although it did not reach statistical significance. Also, the percentage of infected hepatocytes correlated with HCV-RNA concentration in serum in both children (r=0.683, P=0.001) and adults (r=0.768, P=0.001). The results show thatliver damage in children with chronic hepatitis C is not related to the extent of infection in the liver. This findings support the hypothesis of that liver injury in chronic HCV infection is mediated by the host immune response. J. Med. Virol. 64: 1-5, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:31:58