Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evaluation of endothelial cell integrins after in vitro contact with polyethylene terephthalate
Autore:
Cenni, E; Granchi, D; Verri, E; Remiddi, G; Cavedagna, D; Di Leo, A;
Indirizzi:
Ist Ortoped Rizzoli, I-40136 Bologna, Italy Ist Ortoped Rizzoli Bologna Italy I-40136 izzoli, I-40136 Bologna, Italy Policlin S Orsola, Ist Fisiopatol Riproduz, Bologna, Italy Policlin S Orsola Bologna Italy Ist Fisiopatol Riproduz, Bologna, Italy
Titolo Testata:
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
fascicolo: 4, volume: 12, anno: 2001,
pagine: 345 - 349
SICI:
0957-4530(200104)12:4<345:EOECIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR GRAFTS; NEOINTIMAL HYPERPLASIA; ADHESION; EXPRESSION; DACRON; PROSTHESES; ADSORPTION; MOLECULES; PROTEINS; PEPTIDES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Cenni, E Ist Ortoped Rizzoli, Via Barbiano 1-10, I-40136 Bologna, Italy Ist Ortoped Rizzoli Via Barbiano 1-10 Bologna Italy I-40136 taly
Citazione:
E. Cenni et al., "Evaluation of endothelial cell integrins after in vitro contact with polyethylene terephthalate", J MAT S-M M, 12(4), 2001, pp. 345-349

Abstract

The aim of this research was to evaluate the effect of polyethylene terephthalate (Woven Dacron) on the expression of endothelial integrins. Human umbilical vein endothelial cells were cultured on the material for 24 h. The integrins VLA-2 (alpha (2)beta (1)-CD49b/CD29), receptor for laminin and collagen, VLA-5 (alpha (5)beta (1)-CD49e/CD29), receptor for fibronectin, VLA-6 (alpha (6)beta (1)-CD49f/CD29), receptor for laminin, and alphaV beta (3)-CD51/CD61 (receptor for vitronectin) were evaluated by flow cytometry. After contact with polyethylene terephthalate, a slight but significant decrease in the percentage of both CD29 and CD49e positive cells was observed, which suggests a lower number of cells expressing the fibronectin receptor alpha (5)beta (1). Moreover, a significant increase in the mean channel for CD49b and for the vitronectin receptor CD51/CD61 was observed. The reduction in the fibronectin receptor could account for the poor endothelializationobserved in vivo on polyethylene terephthalate. The increased expression of the vitronectin receptor, favoring the migration of smooth muscle cells, could give some information about the pathogenesis of intimal hyperplasia, which is a complication of vascular grafts. (C) 2001 Kluwer Academic Publishers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:45:28