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Titolo:
Multicomponent systems of econazole with hydroxyacids and cyclodextrins
Autore:
Mura, P; Faucci, MT; Manderioli, A; Bramanti, G;
Indirizzi:
Univ Florence, Dipartimento Sci Farmaceut, I-50121 Florence, Italy Univ Florence Florence Italy I-50121 Farmaceut, I-50121 Florence, Italy
Titolo Testata:
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
fascicolo: 1-2, volume: 39, anno: 2001,
pagine: 131 - 138
SICI:
1388-3127(200102)39:1-2<131:MSOEWH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CYCLODEXTRIN; INCLUSION COMPLEXES; DISSOLUTION RATE; MICONAZOLE; SUPERSATURATION; ENHANCEMENT;
Keywords:
multicomponent complexes; econazole; cyclodextrins; hydroxyacids; solubilization; dissolution rate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Mura, P Univ Florence, Dipartimento Sci Farmaceut, Via G Capponi 9, I-50121 Florence, Italy Univ Florence Via G Capponi 9 Florence Italy I-50121 rence, Italy
Citazione:
P. Mura et al., "Multicomponent systems of econazole with hydroxyacids and cyclodextrins", J INCL P MA, 39(1-2), 2001, pp. 131-138

Abstract

The effect of the type of cyclodextrin (alpha-, beta-, gamma-, hydroxypropyl-beta -CD) and of hydroxyacid (tartaric, citric, gluconic, malic, lactic)on the solubility enhancement by multicomponent complexation of econazole,a poorly water soluble base-type drug, was studied. A synergistic effect was found in ternary systems, largely more effective than corresponding binary complexes and salts. Moreover, the presence of a third component made effective the use of gamma -CD, which had no solubilizing power in binary systems. The solubilizing efficiency of multicomponent systems was not relatedto the solubilities of the corresponding salts or binary complexes. Phase-solubility analysis at different temperatures was also used to investigate the interaction of econazole with cyclodextrins, alone or in the presence of hydroxyacid. The best 1 : 1 : 1 molar ratio system was that with alpha -CD and malic acid which showed the best solubilizing power and the highest stability constant of the ternary complex. Ternary alpha -CD products, prepared by co-grinding, co-evaporation or colyophilization, were characterized by Differential Scanning Calorimetry and tested for dissolution properties. The higher solubilizing properties of multicomponent systems were reflected in better drug dissolution rates from their solid systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:37:45