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Titolo:
Effects of high sodium intake on cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats
Autore:
Takeda, Y; Yoneda, T; Demura, M; Furukawa, K; Miyamori, I; Mabuchi, H;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 2, Kanazawa, Ishikawa 920, JapanKanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Kanazawa Univ, Sch Med, Dept Hlth Sci, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Fukui Med Sch, Dept Internal Med 3, Fukui 91011, Japan Fukui Med Sch Fukui Japan 91011 Dept Internal Med 3, Fukui 91011, Japan
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 3, volume: 19, anno: 2001,
parte:, 2
pagine: 635 - 639
SICI:
0263-6352(200103)19:3<635:EOHSIO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-II; VASCULAR ALDOSTERONE; CARDIAC FIBROSIS; BIOSYNTHESIS; HYPERTROPHY; METABOLISM; BLOCKADE; SYNTHASE; INJURY; HEART;
Keywords:
blood vessels; heart aldosterone; stroke-prone spontaneously hypertensive rats; CYP11B2; messenger RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, Y Kanazawa Univ, Sch Med, Dept Internal Med 2, 13-1 Takara Machi, Kanazawa, Ishikawa 920, Japan Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan 920 apan
Citazione:
Y. Takeda et al., "Effects of high sodium intake on cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats", J HYPERTENS, 19(3), 2001, pp. 635-639

Abstract

Objectives Aldosterone is synthesized in extra-adrenal tissues such as thevasculature, heart and brain, The mechanisms underlying the effect of highsalt intake on the development and acceleration of vascular injury and cardiac hypertrophy in the stroke-prone spontaneously hypertensive rats (SHRSP) are still not clear, The goal of this study was to determine whether highsalt intake increases cardiovascular aldosterone synthesis in SHRSP. Methods Four-week-old SHRSP were given tap water or 0.9% NaCl solution forhydration for 4 weeks in addition to a normal salt diet. isolated rat mesenteric arteries and hearts were perfused for 2 h, and the perfusate was analysed by high-performance liquid chromatography, The concentrations of aldosterone synthase gene (CYP11B2) mRNA and angiotensin ii receptor (AT1R) mRNA were determined by competitive polymerase chain reaction. Results Salt-loaded SHRSP had higher blood pressures than SHRSP with normal salt intake. Plasma aldosterone concentrations and plasma renin activity were decreased by high salt intake. Aldosterone production, the expression of CYP11B2 mRNA and ATI R mRNA in mesenteric arteries and hearts were significantly increased by high salt intake. Conclusions These results suggest that high salt intake increases aldosterone production and expression of the AT1R mRNA in the cardiovascular tissuein SHRSP, which may contribute to the development of malignant hypertension in salt-loaded SH RSP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 15:49:45