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Titolo:
Pulse wave velocity as endpoint in large-scale intervention trial. The Complior (R) study
Autore:
Asmar, R; Topouchian, J; Pannier, B; Benetos, A; Safar, M;
Indirizzi:
Inst CardioVasc, F-75016 Paris, France Inst CardioVasc Paris France F-75016 t CardioVasc, F-75016 Paris, France Hop Broussais, Serv Med 1, F-75674 Paris, France Hop Broussais Paris France F-75674 is, Serv Med 1, F-75674 Paris, France
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 4, volume: 19, anno: 2001,
pagine: 813 - 818
SICI:
0263-6352(200104)19:4<813:PWVAEI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME-INHIBITION; ESSENTIAL-HYPERTENSION; ARTERIAL HEMODYNAMICS; BLOOD-PRESSURE; DOUBLE-BLIND; HYDROCHLOROTHIAZIDE; PERINDOPRIL; COMBINATION; DIAMETER;
Keywords:
angiotensin converting enzyme (ACE) inhibition; antihypertensive therapy; arterial stiffness; feasibility; hypertension; pulse wave velocity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Asmar, R Inst CardioVasc, 21 Blvd Delessert, F-75016 Paris, France Inst CardioVasc 21 Blvd Delessert Paris France F-75016 s, France
Citazione:
R. Asmar et al., "Pulse wave velocity as endpoint in large-scale intervention trial. The Complior (R) study", J HYPERTENS, 19(4), 2001, pp. 813-818

Abstract

Objective To evaluate the ability of an antihypertensive therapy to improve arterial stiffness as assessed by aortic pulse wave velocity (PWV) in a large population of hypertensive patients. Setting Sixty-nine healthcare centres, private and institutional (19 countries). Patients Subjects aged 18-79 years, with essential hypertension. A total of 2187 patients were enrolled; 1703 (52% male) completed the study: mean age = 50 +/- 12 years; mean baseline systolic/diastolic blood pressure (S/D BP) = 158 +/- 15/98 +/- 7 mmHg; mean baseline carotid-femoral PWV = 11.6 +/-2.4 m/s. Interventions Patients were treated for 6 months, starting with perindopril (angiotensin converting enzyme (ACE) inhibitor) 4 mg once daily (OD), increased to 8 mg OD, and combined to diuretic (indapamide 2.5 mg OD) if BP was uncontrolled (> 140/90 mmHg),Results It was feasible to measure carotid-femoral PWV using the automaticdevice Complior (R) at inclusion, 2 and 6 months, along with conventional BP assessments in a population of 1703 patients. Significant decreases (P <0.001) in BP (systolic: -23.7 <plus/minus> 16.8, diastolic: -14.6 +/- 10 mmHg), and carotid-femoral PWV (-1.1 +/- 1.4 m/s) were obtained at 2 and 6 months,Conclusions The Complier Study is the first study to show the feasibility of a large-scale intervention trial using PWV as the endpoint in hypertensive patients. Adequate results may be obtained using an automatic device andrigorous criteria for assessment. A long-term controlled intervention study is needed to confirm the results of the present uncontrolled trial. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:04:18