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Titolo:
Catalog of 320 single nucleotide polymorphisms (SNPs) in 20 quinone oxidoreductase and sulfotransferase genes
Autore:
Iida, A; Sekine, A; Saito, S; Kitamura, Y; Kitamoto, T; Osawa, S; Mishima, C; Nakamura, Y;
Indirizzi:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab,Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 l Med Lab,Minato Ku, Tokyo 1088639, Japan Inst Phys & Chem Res, RIKEN, SNP Res Ctr, Lab Genotyping, Tokyo, Japan Inst Phys & Chem Res Tokyo Japan Res Ctr, Lab Genotyping, Tokyo, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 4, volume: 46, anno: 2001,
pagine: 225 - 240
SICI:
1434-5161(2001)46:4<225:CO3SNP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-CANCER; CANDIDATE GENES; ASSOCIATION; ALLELE; RISK; IDENTIFICATION; DIAGNOSIS; DISORDERS; BIOLOGY; CLONING;
Keywords:
single nucleotide polymorphism (SNP); quinone oxidoreductase; sulfotransferase; drug-metabolizing enzymes; nonsynonymous substitution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, Y Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab,MinatoKu, 4-6-1 Shirokanedai, Tokyo 1088639, Japan Univ Tokyo 4-6-1 ShirokanedaiTokyo Japan 1088639 8639, Japan
Citazione:
A. Iida et al., "Catalog of 320 single nucleotide polymorphisms (SNPs) in 20 quinone oxidoreductase and sulfotransferase genes", J HUM GENET, 46(4), 2001, pp. 225-240

Abstract

Single nucleotide polymorphisms (SNPs) in genes encoding drug-metabolizingenzymes, transporters, receptors, and other drug targets have been widely implicated as contributors to differences among individuals as regards the efficacy and toxicity of many medications, as well as the susceptibility tocomplex diseases. By combining the polymerase chain reaction (PCR) technique with direct sequencing, we screened genomic DNAs from 48 Japanese Volunteers for SNPs in genes encoding three quinone oxidoreductases (NQO1, NQO2, and PIG3) and 17 sulfotransferases (SULT1A1, SULT1A2, SULT1A3, SULT1C1, SULT1C2, SULT2A1, SULT2B1, ST1B2 TPST1, TPST2, SULTX3, STE, CST, HNK-1 ST, CHST2, CHST4, and CHST5). In all, we identified 320 SNPs from these 20 loci: 22 within coding elements, 21 in 5' flanking regions, 10 in 5' untranslated regions, 223 in introns, 19 in 3' untranslated regions, and 25 in 3' flanking regions. The ratio of transitions to transversions was approximately 2.3to 1. Of the 22 coding SNPs, 6 were nonsynonymous substitutions that resulted in amino-acid substitutions. The high-density SNP maps we constructed from this data for each of the quinone oxidoreductases and sulfotransferasesexamined here should provide useful information for investigations designed to detect association(s) between genetic variations and common diseases or responsiveness to drug therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:51:45