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Titolo:
The C825T polymorphism in the G-protein beta 3 subunit gene and diabetic complications in IDDM patients
Autore:
Shcherbak, NS; Schwartz, EI;
Indirizzi:
St Petersburg State Med Univ, Mol Cardiol Lab, St Petersburg 197189, Russia St Petersburg State Med Univ St Petersburg Russia 197189 197189, Russia
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 4, volume: 46, anno: 2001,
pagine: 188 - 191
SICI:
1434-5161(2001)46:4<188:TCPITG>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESSENTIAL-HYPERTENSION; 825T ALLELE; VARIANT; NEPHROPATHY; ASSOCIATION; ACTIVATION; GNB3; DNA;
Keywords:
genetic predisposition to disease; GNB3; diabetic nephropathy; diabetic retinopathy; diabetic neuropathy; diabetes mellitus; insulin-dependent;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Shcherbak, NS St Petersburg State Med Univ, Mol Cardiol Lab, L Tolstoy St 6-8, St Petersburg 197189, Russia St Petersburg State Med Univ L Tolstoy St6-8 St Petersburg Russia 197189
Citazione:
N.S. Shcherbak e E.I. Schwartz, "The C825T polymorphism in the G-protein beta 3 subunit gene and diabetic complications in IDDM patients", J HUM GENET, 46(4), 2001, pp. 188-191

Abstract

Complications of insulin-dependent diabetes mellitus (IDDM) are a major cause of morbidity and mortality; however, the mechanisms of their development are still to be elucidated. Genetic susceptibility contributes to the pathogenesis of nephropathy in IDDM. Enhanced G-protein activation. a cellularphenotype observed in cultured cells from patients with essential hypertension. was recently documented in IDDM subjects with nephropathy. A C825T polymorphism was recently described in GNB3, the gene encoding the beta 3 subunit of heterotrimeric G-proteins. This genetic variant has been associatedwith enhanced G-protein activation. The 825T allele was observed more frequently in a group with essential hypertension. We analyzed the role of the C825T polymorphism in the predisposition to diabetic complications in IDDM. In this study, we investigated the frequency of this polymorphism in a large case-control study and found no association of the 825T allele with diabetic nephropathy, retinopathy, and neuropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:33:03