Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The c-Jun NH2-terminal kinase3 (JNK3) gene: genomic structure, chromosomalassignment, and loss of expression in brain tumors
Autore:
Yoshida, S; Fukino, K; Harada, H; Nagai, H; Imoto, I; Inazawa, J; Takahashi, H; Teramoto, A; Emi, M;
Indirizzi:
Nippon Med Sch, Inst Gerontol, Dept Mol Biol, Nakahara Ku, Kawasaki, Kanagawa 2118533, Japan Nippon Med Sch Kawasaki Kanagawa Japan 2118533 i, Kanagawa 2118533, Japan Nippon Med Sch, Dept Neurosurg, Kawasaki, Kanagawa, Japan Nippon Med Sch Kawasaki Kanagawa Japan rosurg, Kawasaki, Kanagawa, Japan Tokyo Med & Dent Univ, Med Res Inst, Tokyo, Japan Tokyo Med & Dent Univ Tokyo Japan Dent Univ, Med Res Inst, Tokyo, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 4, volume: 46, anno: 2001,
pagine: 182 - 187
SICI:
1434-5161(2001)46:4<182:TCNK(G>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMORPHISM; CARCINOMAS; REGION; JAPAN; LOCUS;
Keywords:
JNK3; brain tumor; genomic structure; single-nucleotide polymorphism; 4q21-22;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Emi, M Nippon Med Sch, Inst Gerontol, Dept Mol Biol, Nakahara Ku, 1-396 Kosugi-cho, Kawasaki, Kanagawa 2118533, Japan Nippon Med Sch 1-396 Kosugi-choKawasaki Kanagawa Japan 2118533 pan
Citazione:
S. Yoshida et al., "The c-Jun NH2-terminal kinase3 (JNK3) gene: genomic structure, chromosomalassignment, and loss of expression in brain tumors", J HUM GENET, 46(4), 2001, pp. 182-187

Abstract

By examining 19 human cell lines derived from brain tumors for altered expression of expressed sequence tags (ESTs) in chromosomal hand 4q21-22, we detected loss of expression, in 10 cell lines, of two sequences, WI6336 and WI7913. Both corresponded to the c-Jun NH2-terminal kinase (JNK) 3. In the present study, genomic cloning revealed that the JNK3 gene consists of 14 exons interrupted by 13 introns: its transcription-initiation site is withinexon 3 and the termination codon lies in exon 14. Fluorescence in situ hybridization (FISH) and radiation-hybrid mapping confirmed the gene to 4q21-22. Together with prior evidence that, in JNK3-deficient mice, the JNK3 signaling pathway mediates apoptosis in central nervous tissue, our results suggest that loss of expression of the JNK3 gene may play an important role inthe development of brain tumors in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:21:52