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Titolo:
Effects of hepatic lipase gene promoter nucleotide variations on serum HDLcholesterol concentration in the general Japanese population
Autore:
Inazu, A; Nishimura, Y; Terada, Y; Mabuchi, H;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 2, Kanazawa, Ishikawa 9200934, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9200934 wa, Ishikawa 9200934, Japan Kanazawa Univ, Sch Hlth Sci, Dept Lab Sci, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 4, volume: 46, anno: 2001,
pagine: 172 - 177
SICI:
1434-5161(2001)46:4<172:EOHLGP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; CORONARY-ARTERY DISEASE; ESTER TRANSFER PROTEIN; C-514T POLYMORPHISM; TRIGLYCERIDE LIPASE; PLASMA; COMMON; LIPC; ASSOCIATION; SEQUENCE;
Keywords:
hepatic lipase; single-nucleotide polymorphism; HDL; promoter; cholesteryl ester transfer protein; lipoprotein lipase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Inazu, A Kanazawa Univ, Sch Med, Dept Internal Med 2, 13-1 Takara-machi, Kanazawa, Ishikawa 9200934, Japan Kanazawa Univ 13-1 Takara-machi Kanazawa Ishikawa Japan 9200934 n
Citazione:
A. Inazu et al., "Effects of hepatic lipase gene promoter nucleotide variations on serum HDLcholesterol concentration in the general Japanese population", J HUM GENET, 46(4), 2001, pp. 172-177

Abstract

Genetic factors may play a major role in determining serum high-density lipoprotein (HDL) cholesterol (HDL-C) levels in the general population. Cholesteryl ester transfer protein (CETP) is a strong genetic factor as a determinant of HDL-C levels in Japanese, whereas hepatic lipase (HL) plays a predominant role in Caucasian populations. We investigated the effects of HL gene promoter polymorphisms on HDL-C levels in a general population of Japanese men (n = 299). An HL promoter polymorphism of -514C/T explained a considerable variance of HDL-C (2.9%), as compared with CETP mutations of D442G and IVS14 + 1G > A (3.6% and 1.9%). HL promoter variation of the -514C/C genotype, reported to have high HL activity, had significant effects on decreasing HDL-C levels (-3.8 mg/dl), but -514T allele carriers had a weak effecton increasing HT)L-C levels. The frequency of the -514T allele was three times higher (0.50) in the Japanese than in Caucasian populations (0.15-0.19). Thus. the higher frequency of the HL -514T allele, along with CETP gene mutations, could explain about 9% of phenotypic variability of HDL-C. Thesegenetic attributes may be among the many factors that contribute to the relatively higher serum HDL-C levels in Japanese subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:24:24