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Titolo:
The effect of insulin and sulodexide (Vessel Due F) on diabetic foot syndrome - Pilot study in elderly patients
Autore:
Koblik, T; Sieradzki, J; Sendur, R; Biernat, J; Czarnobilski, K; Gryz, E; Pawlik, W; Szczudlik, A; Gaddi, A;
Indirizzi:
Jagiellonian Univ, Clin Metab Dis, Krakow, Poland Jagiellonian Univ Krakow Poland an Univ, Clin Metab Dis, Krakow, Poland
Titolo Testata:
JOURNAL OF DIABETES AND ITS COMPLICATIONS
fascicolo: 2, volume: 15, anno: 2001,
pagine: 69 - 74
SICI:
1056-8727(200103/04)15:2<69:TEOIAS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER DOPPLER FLOWMETRY; SKIN MICROCIRCULATION; NEUROPATHY; GLYCOSAMINOGLYCAN; PREVENTION; THERAPY; ULCERS; METAANALYSIS; AMPUTATION; DISEASE;
Keywords:
diabetic foot syndrome; peripheral diabetic neuropathy; glycosaminoglycans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Gaddi, A St Orsola & Marcello Malpighi Hosp, Dept Internal Med & Appl Biotechnol, Via Massarenti 9, I-40138 Bologna, Italy St Orsola & Marcello Malpighi Hosp Via Massarenti 9 Bologna Italy I-40138
Citazione:
T. Koblik et al., "The effect of insulin and sulodexide (Vessel Due F) on diabetic foot syndrome - Pilot study in elderly patients", J DIABET C, 15(2), 2001, pp. 69-74

Abstract

To assess the efficacy of insulin plus sulodexide (a mixture of 80% heparin-like substances and 20% dermatan sulphate) on diabetic ulcers, and its influence on foot sl;in microcirculation and diabetic neuropathy. Two groups of diabetic patients, suffering from severe neuropathy and ulceration, wererandomly assigned to insulin (I) plus sulodexide (S) (n = 12) or insulin plus placebo (P) (n=6) therapy, for 10 weeks. Laser Doppler assessment of foot skin flow (LDF), at rest and 30 or 60 s after arterial occlusion, and nerve conduction tests (sensorial evoked and motoric conduction potentials) have been evaluated in both groups. Postischaemic flow was 2.5 times shorterin ulcerated vs. non-ulcerated feet in diabetic patients. A significant increase in flows after 30 and 60 s ischaemia was detected in both groups at the end of therapy (IS group, ulcerated foot, LDF=60 s: from 99.1 +/- 14.3 to 218.6 +/- 28.6 PU, P<.001. IP group=from 110.5 <plus/minus> 13.0 to 164.8 +/- 15.4 PU, P<.05). The length of reactive hyperaemia was higher in IS vs. If group (IS: from 30.3 <plus/minus> 2.9 to 43.9 +/- 2.2 s, P<.001; IP: from 28.7 <plus/minus> 3.0 to 33.3 +/- 3,3 s, ns). Ninety-two percent of ulcers heals in a mean time of 46.4 days (IS group) vs. 83% and 63.0 days, respectively, in IP group. Nerve conduction studies have not demonstrated within- and between-group differences. Sulodexide and insulin improve the postischaemic skin flow in ulcerated feet, without affecting nerve conduction tests. The effect of sulodexide results additive to insulin; it is clinically relevant, in the view of the possibility of reducing the time needed to completely heal ulcers. The ultimate validation of these preliminary resultsrequires extensive trials. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:24:52