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Titolo:
Histologic criteria for the diagnosis of mycosis fungoides: proposal for agrading system to standardize pathology reporting
Autore:
Guitart, J; Kennedy, J; Ronan, S; Chmiel, JS; Hsiegh, YC; Variakojis, D;
Indirizzi:
Northwestern Univ, Sch Med, Dept Dermatol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 pt Dermatol, Chicago, IL 60611 USA Univ Illinois, Coll Med, Dept Pathol, Chicago, IL 60612 USA Univ IllinoisChicago IL USA 60612 ed, Dept Pathol, Chicago, IL 60612 USA Northwestern Univ, Sch Med, Dept Prevent Med, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Prevent Med, Chicago, IL 60611 USA
Titolo Testata:
JOURNAL OF CUTANEOUS PATHOLOGY
fascicolo: 4, volume: 28, anno: 2001,
pagine: 174 - 183
SICI:
0303-6987(200104)28:4<174:HCFTDO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL LYMPHOMA; REPRODUCIBILITY; CLONALITY; STAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Guitart, J Northwestern Univ, Sch Med, Dept Dermatol, 695 N St Clair,Suite19-150, Chicago, IL 60611 USA Northwestern Univ 695 N St Clair,Suite 19-150 Chicago IL USA 60611
Citazione:
J. Guitart et al., "Histologic criteria for the diagnosis of mycosis fungoides: proposal for agrading system to standardize pathology reporting", J CUT PATH, 28(4), 2001, pp. 174-183

Abstract

Background: The histological diagnosis of early lesions of mycosis fungoides (MF) is often difficult for dermatopathologists and prior studies have shown a low agreement rate among pathologists. An important reason for such difficulty may be the lack of specific histological criteria. Methods: We tested a new method to interpret and report biopsies suspicious for MF. The method is based on a grading system reflecting the pathologist's degree of diagnostic certainty. A panel of four pathologists independently assessed a set of 50 biopsies suspicious for MF first without (Phase I)and subsequently with specific histological criteria (Phase II). A third Phase was carried out after a training session, using a new set of cases with corresponding immunophenotyping and gene rearrangement analysis. Weightedand unweighted kappa statistics were used to assess inter- and intra-pathologist variation. Results: The consensus rate among pathologists improved from 48% in Phase I to 76% in Phase III. Overall precision weighted kappas increased from 0.630 in Phase I to 0.854 in Phase III, indicating excellent inter-pathologistagreement by Phase III. There was a significant association between the presence of an abnormal phenotype and/or T-cell clonality and a higher diagnostic score. Conclusions: The use of uniform criteria and training sessions can substantially improve the consensus rate among pathologists in the diagnosis of MF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:26:58