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Titolo:
Membrane potential fluctuations determine the precision of spike timing and synchronous activity: A model study
Autore:
Kretzberg, J; Egelhaaf, M; Warzecha, AK;
Indirizzi:
Univ Bielefeld, Fak Biol, Lehrstuhl Neurobiol, D-33501 Bielefeld, Germany Univ Bielefeld Bielefeld Germany D-33501 iol, D-33501 Bielefeld, Germany
Titolo Testata:
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
fascicolo: 1, volume: 10, anno: 2001,
pagine: 79 - 97
SICI:
0929-5313(200101)10:1<79:MPFDTP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISUAL RESPONSE PROPERTIES; RETINAL GANGLION-CELLS; NOISY CABLE STRUCTURES; SENSITIVE NEURON; CORTICAL-NEURONS; THEORETICAL-ANALYSIS; TEMPORAL PRECISION; MOTION INFORMATION; ESTIMATING SIGNALS; BLOWFLY FLIGHT;
Keywords:
spike mechanism; model; spike timing; synchronization; reliability; neural coding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Kretzberg, J Univ Bielefeld, Fak Biol, Lehrstuhl Neurobiol, Postfach 10 0131, D-33501 Bielefeld, Germany Univ Bielefeld Postfach 10 01 31 BielefeldGermany D-33501 y
Citazione:
J. Kretzberg et al., "Membrane potential fluctuations determine the precision of spike timing and synchronous activity: A model study", J COMPUT N, 10(1), 2001, pp. 79-97

Abstract

It is much debated on what time scale information is encoded by neuronal spike activity. With a phenomenological model that transforms time-dependentmembrane potential fluctuations into spike trains, we investigate constraints for the timing of spikes and for synchronous activity of neurons with common input. The model of spike generation has a variable threshold that depends on the time elapsed since the previous action potential and on the preceding membrane potential changes. To ensure that the model operates in a biologically meaningful range, the model was adjusted to fit the responses of a fly visual interneuron to motion stimuli. The dependence of spike timing on the membrane potential dynamics was analyzed. Fast membrane potentialfluctuations are needed to trigger spikes with a high temporal precision. Slow fluctuations lead to spike activity with a rate about proportional to the membrane potential. Thus, for a given level of stochastic input, the frequency range of membrane potential fluctuations induced by a stimulus determines whether a neuron can use a rate code or a temporal code. The relationship between the steepness of membrane potential fluctuations and the timing of spikes has also implications for synchronous activity in neurons withcommon input. Fast membrane potential changes must be shared by the neurons to produce synchronous activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:29:17