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Titolo:
Sensitivity to naloxone of the behavioral signs of morphine withdrawal andc-Fos expression in the rat CNS: A quantitative dose-response analysis
Autore:
Le Guen, S; Gestreau, C; Besson, JM;
Indirizzi:
INSERM, U161, F-75014 Paris, France INSERM Paris France F-75014INSERM, U161, F-75014 Paris, France EPHE, F-75014 Paris, France EPHE Paris France F-75014EPHE, F-75014 Paris, France
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 2, volume: 433, anno: 2001,
pagine: 272 - 296
SICI:
0021-9967(20010430)433:2<272:STNOTB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-COERULEUS NEURONS; NUCLEUS-TRACTUS-SOLITARII; CENTRAL-NERVOUS-SYSTEM; MU-OPIOID RECEPTORS; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; ELECTRON-MICROSCOPIC OBSERVATION; PRECIPITATED OPIATE WITHDRAWAL; CORTICOTROPIN-RELEASING FACTOR; PITUITARY-ADRENAL RESPONSE; CONDITIONED TASTE-AVERSION;
Keywords:
addiction; immediate-early genes; mapping; dependence;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
189
Recensione:
Indirizzi per estratti:
Indirizzo: Le Guen, S INSERM, U161, 2 Rue Alesia, F-75014 Paris, France INSERM 2 Rue Alesia Paris France F-75014 F-75014 Paris, France
Citazione:
S. Le Guen et al., "Sensitivity to naloxone of the behavioral signs of morphine withdrawal andc-Fos expression in the rat CNS: A quantitative dose-response analysis", J COMP NEUR, 433(2), 2001, pp. 272-296

Abstract

Several studies have used c-Fos expression to delineate the neural substrate underlying naloxone-precipitated morphine withdrawal (MW). However, because behavioral manifestations of MW depend on both the degree of dependenceand the doses of naloxone (NAL), a comprehensive study would require examining c-Fos expression in relation with the degree of MW. Here, changes in behavior and in c-Fos-like immunoreactivity (FLI) were studied in the same rats after injection of three doses of NAL to precipitate various degrees ofMW. Fifteen established signs of MW were examined for 1 hour after NAL injection, and FLI was quantified in 52 regions of the brain and in the lumbosacral spinal cord. Linear regression analyses were used to examine changes in numbers of signs and FLI neurons with the doses of NAL, and data were considered dose-related for a statistical level of significance of P < 0.05. In summary, autonomic signs of MW increased in a dose-related manner, whereas somatomotor signs did not. After MW, 33 central nervous system regions exhibited significant increases in FLI and were, thus, considered as important neural correlates of MW. Twenty of them displayed dose-related increasesin c-Fos expression and correspond to regions related to autonomic functions. Low c-Fos expression was detected in some regions involved in motor control or in reward, suggesting either their minor role in MW or a limitationof the technique. This dose-response analysis suggests that the increase in the severity of autonomic manifestations of MW is associated with a gradual activation of major structures of the autonomic nervous system. J. Comp. Neurol. 433:272-297, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:41:14