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Titolo:
Human thymus contains IFN-alpha-producing CD11c(-), myeloid CD11c(+) and mature interdigitating dendritic cells
Autore:
Bendriss-Vermare, N; Barthelemy, C; Durand, I; Bruand, C; Dezutter-Dambuyant, C; Moulian, N; Berrih-Aknin, S; Caux, C; Trinchieri, G; Briere, F;
Indirizzi:
Schering Plough, Lab Immunol Res, F-69571 Dardilly, France Schering Plough Dardilly France F-69571 ol Res, F-69571 Dardilly, France IMTIX Sangstat, Marcy Letoile, France IMTIX Sangstat Marcy Letoile France TIX Sangstat, Marcy Letoile, France Ctr Hosp Edouard Herriot, INSERM, U346, Lyon, France Ctr Hosp Edouard Herriot Lyon France erriot, INSERM, U346, Lyon, France Hop Marie Lannelongue, Enseignement Specif Associe 8078, F-92350 Le Plessis Robinson, France Hop Marie Lannelongue Le Plessis Robinson France F-92350 obinson, France
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 7, volume: 107, anno: 2001,
pagine: 835 - 844
SICI:
0021-9738(200104)107:7<835:HTCICM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PERIPHERAL-BLOOD; T-CELLS; B-CELLS; NATURAL-KILLER; PRECURSOR POPULATION; IN-VIVO; SPI-B; DIFFERENTIATION; IDENTIFICATION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Briere, F Schering Plough, Lab Immunol Res, 27 Chemin Peupliers,BP 11, F-69571 Dardilly, France Schering Plough 27 Chemin Peupliers,BP 11 Dardilly France F-69571
Citazione:
N. Bendriss-Vermare et al., "Human thymus contains IFN-alpha-producing CD11c(-), myeloid CD11c(+) and mature interdigitating dendritic cells", J CLIN INV, 107(7), 2001, pp. 835-844

Abstract

Three distinct dendritic cell (DC) subsets capable of stimulating allogeneic naive T cells were isolated from human thymus. The most abundant subset was represented by plasmacytoid DCs (pDCs), which secreted high amounts of IFN-alpha upon stimulation with inactivated influenza virus and thus likelycorrespond to the recentlyidentified peripheral blood natural IFN-alpha/beta -producing cells (IPCs). Like those latter cells, thymic pDCs had distinctive phenotypic features (i.e., Lin(-), HLA-DRint, IL-3R alpha (hi), CD45RA(hi), CD11c(-), CD13-, and CD3310) and developed into mature DCs upon culture in IL-3 and CD40L. Of the two other DC subsets, one displayed a phenotype of immature myeloid DCs (imDCs) (HLA-DRint, CD111c(+), CD13(+), CD33(+)), and the other represented HLA-DRhi CD11c(+) mature DCs (mDCs). Since theyalso expressed DC-LAMP, these mDCs appear to correspond to interdigitatingdendritic cells (IDCs). Thymic pDCs, but not myeloid imDCs, strongly expressed lymphoid-specific transcripts such as pre-T alpha, lambda -like, and Spi-B, thereby suggesting a possible lymphoid origin. The detection of Spi-BmRNA, not only upon in vitro maturation ofpDCs, but also in freshly purified IDCs, suggests that in vivo pDCs may differentiate into IDCs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:29:10