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Titolo:
Adjusting for multiple testing - when and how?
Autore:
Bender, R; Lange, S;
Indirizzi:
Univ Bielefeld, Sch Publ Hlth, Inst Med Stat & Epidemiol, D-33501 Bielefeld, Germany Univ Bielefeld Bielefeld Germany D-33501 iol, D-33501 Bielefeld, Germany Ruhr Univ Bochum, Dept Med Informat Biometry & Epidemiol, D-44780 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-44780 idemiol, D-44780 Bochum, Germany
Titolo Testata:
JOURNAL OF CLINICAL EPIDEMIOLOGY
fascicolo: 4, volume: 54, anno: 2001,
pagine: 343 - 349
SICI:
0895-4356(200104)54:4<343:AFMT-W>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CLINICAL-TRIALS; END-POINTS; SUBGROUP ANALYSES; INTERIM ANALYSES; P-VALUES; BONFERRONI; ADJUSTMENT; VARIANCE; ENDPOINTS; OUTCOMES;
Keywords:
multiple hypotheses testing; P value; error rates; Bonferroni method; adjustment for multiple testing; UKPDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Bender, R Univ Bielefeld, Sch Publ Hlth, Inst Med Stat & Epidemiol, POB 100131, D-33501 Bielefeld, Germany Univ Bielefeld POB 100131 Bielefeld Germany D-33501 ld, Germany
Citazione:
R. Bender e S. Lange, "Adjusting for multiple testing - when and how?", J CLIN EPID, 54(4), 2001, pp. 343-349

Abstract

Multiplicity of data, hypotheses, and analyses is a common problem in biomedical and epidemiological research. Multiple testing theory provides a framework for defining and controlling appropriate error rates in order to protect against wrong conclusions. However, the corresponding multiple test procedures are underutilized in biomedical and epidemiological research. In this article, the existing multiple test procedures are summarized for the most important multiplicity situations. It is emphasized that adjustments for multiple testing are required in confirmatory studies whenever results from multiple tests have to be combined in one final conclusion and decision. In case of multiple significance tests a note on the error rate that will be controlled for is desirable. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 29/03/20 alle ore 18:18:17