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Titolo:
Biopartitioning micellar chromatography: an in vitro technique for predicting human drug absorption
Autore:
Molero-Monfort, M; Escuder-Gilabert, L; Villaneuva-Camanas, RM; Sagrado, S; Medina-Hernandez, MJ;
Indirizzi:
Univ Valencia, Dept Quim Analit, E-46100 Valencia, Spain Univ Valencia Valencia Spain E-46100 uim Analit, E-46100 Valencia, Spain
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 2, volume: 753, anno: 2001,
pagine: 225 - 236
SICI:
1387-2273(20010405)753:2<225:BMCAIV>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETENTION-ACTIVITY RELATIONSHIP; ACTIVITY RELATIONSHIP MODELS; LIQUID-CHROMATOGRAPHY; INTESTINAL-ABSORPTION; IMMOBILIZED-LIPOSOME; CACO-2 CELLS; PERMEABILITY; TRANSPORT; MONOLAYERS; LINE;
Keywords:
biopartitioning micellar chromatography; oral drug absorption; intestinal epithelium cell lines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Medina-Hernandez, MJ Univ Valencia, Dept Quim Analit, C Vicente Andres Estelles S-N, E-46100 Valencia, Spain Univ Valencia C Vicente Andres Estelles S-N Valencia Spain E-46100
Citazione:
M. Molero-Monfort et al., "Biopartitioning micellar chromatography: an in vitro technique for predicting human drug absorption", J CHROMAT B, 753(2), 2001, pp. 225-236

Abstract

The main oral drug absorption barriers are fluid cell membranes and generally drugs are absorbed by a passive diffusion mechanism. Biopartitioning micellar chromatography (BMC) is a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 under adequate experimental conditions and can be useful to mimic the drug partitioning process in biological systems. In this paper the usefulness of BMC for predicting oral drug absorption in humans is demonstrated. A hyperbolic model has been obtained usingthe retention data of a heterogeneous set of 74 compounds, which shows predictive ability for drugs absorbed by passive diffusion. The model obtainedin BMC is compared with those obtained using the well-known systems (Caco-2 and TC-7) that use intestinal epithelium cell lines. The use of BMC is simple, reproducible and can provide key information about the transport properties of new compounds during the drug discovery process. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:42:51