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Titolo:
Optimized analytical method for cyclosporin A by high-performance liquid chromatography-electrospray ionization mass spectrometry
Autore:
Zhou, L; Tan, D; Theng, J; Lim, L; Liu, YP; Lam, KW;
Indirizzi:
Natl Univ Singapore, Singapore Eye Res Inst, Singapore 117597, Singapore Natl Univ Singapore Singapore Singapore 117597 ngapore 117597, Singapore Natl Univ Singapore, Dept Ophthalmol, Singapore 117597, Singapore Natl Univ Singapore Singapore Singapore 117597 ngapore 117597, Singapore Singapore Natl Eye Ctr, Singapore 168751, Singapore Singapore Natl Eye Ctr Singapore Singapore 168751 pore 168751, Singapore
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1, volume: 754, anno: 2001,
pagine: 201 - 207
SICI:
1387-2273(20010415)754:1<201:OAMFCA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHOLE-BLOOD; METABOLITES; ASSAY; TRANSPLANTATION; QUANTIFICATION;
Keywords:
cyclosporin A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Zhou, L Natl Univ Singapore, Singapore Eye Res Inst, 2 Med Dr 01-15,MD9 Physiol Bldg, Singapore 117597, Singapore Natl Univ Singapore 2 Med Dr 01-15,MD9 Physiol Bldg Singapore Singapore 117597
Citazione:
L. Zhou et al., "Optimized analytical method for cyclosporin A by high-performance liquid chromatography-electrospray ionization mass spectrometry", J CHROMAT B, 754(1), 2001, pp. 201-207

Abstract

The Micromass Platform LCZ mass detector parameters were optimized for simultaneous recording of the protonated (CsA similar toH(+)), sodium adduct (CsA similar to Na+) and potassium adduct (CsA similar toK(+)) of cyclosporin A eluted from a Symmetry Shield RP8 column. The optimized procedure allows a precise analysis of CsA in whole blood or serum without removal of salts prior to analysis. The ratio of the three forms of CsA varied depending on the assay condition and the types of specimens being analyzed. The summation of three ionic forms of CsA detected by LC-ESI-MS is a reliable and simple method to assess CsA concentration in the blood. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 19/01/20 alle ore 09:23:41