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Titolo:
Determination of moxifloxacin in growth media by high-performance liquid chromatography
Autore:
Ba, BB; Etienne, R; Ducint, D; Quentin, C; Saux, MC;
Indirizzi:
Univ Bordeaux 2, Fac Pharm, Lab Pharmacocinet & Pharm Clin, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 m Clin, F-33076 Bordeaux, France Univ Bordeaux 2, Fac Pharm, Microbiol Lab, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 ol Lab, F-33076 Bordeaux, France
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1, volume: 754, anno: 2001,
pagine: 107 - 112
SICI:
1387-2273(20010415)754:1<107:DOMIGM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BODY FLUIDS; ULTRAVIOLET DETECTION; DIRECT-INJECTION; PLASMA; 8-METHOXYQUINOLONE; FLUORESCENCE; BAY-12-8039; MODEL; URINE;
Keywords:
Mueller-Hinton broth; moxifloxacin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Ba, BB Univ Bordeaux 2, Fac Pharm, Lab Pharmacocinet & Pharm Clin, Zone Nord,Batiment 1A,146 Rue Leo Saignat, F-33076 Bordeaux, France Univ Bordeaux 2 Zone Nord,Batiment 1A,146 Rue Leo Saignat Bordeaux France F-33076
Citazione:
B.B. Ba et al., "Determination of moxifloxacin in growth media by high-performance liquid chromatography", J CHROMAT B, 754(1), 2001, pp. 107-112

Abstract

A direct injection high-performance liquid chromatographic method with column switching has been developed to determine moxifloxacin in Mueller-Hinton broth. A LiChrocart 4-4 pre-column filled with a LiChrospher 100 RP 18.5 mum and a 150x4.6 mm I.D, column packed with a Supelcozil ABZ+ Plus were used and led to a retention time of 5.70 min. Fluorescence detection allowed one to reach a quantification limit of 0.05 mug/ml with a 100-mul sample size. The standard curves were linear from 0.05 to 3.2 mug/ml. Intra- and inter-day imprecisions within the linearity range were less than or equal to4.76 and less than or equal to5.75%, respectively. The mean relative errors for the same day and the day-to-day inaccuracies ranged from -2.93 to +4.50%and from -1.10 to +6.00%, respectively. The method was demonstrated to be useful for pharmacokinetic-pharmacodynamic studies of moxifloxacin in an invitro model. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:48:03