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Titolo:
Comparison of three analytical methods for quality control of clozapine tablets
Autore:
Raggi, MA; Pucci, V; Bugamelli, F; Volterra, V;
Indirizzi:
Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 harmaceut Sci, I-40126 Bologna, Italy Univ Bologna, Psychiat Clin, I-40123 Bologna, Italy Univ Bologna BolognaItaly I-40123 Psychiat Clin, I-40123 Bologna, Italy
Titolo Testata:
JOURNAL OF AOAC INTERNATIONAL
fascicolo: 2, volume: 84, anno: 2001,
pagine: 361 - 367
SICI:
1060-3271(200103/04)84:2<361:COTAMF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY-ZONE-ELECTROPHORESIS; PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; HUMAN PLASMA; SCHIZOPHRENIC-PATIENTS; ULTRAVIOLET DETECTION; N-DESMETHYLCLOZAPINE; HUMAN-SERUM; METABOLITES; SEPARATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Raggi, MA Univ Bologna, Dept Pharmaceut Sci, Via Belmeloro 6, I-40126 Bologna, Italy Univ Bologna Via Belmeloro 6 Bologna Italy I-40126 logna, Italy
Citazione:
M.A. Raggi et al., "Comparison of three analytical methods for quality control of clozapine tablets", J AOAC INT, 84(2), 2001, pp. 361-367

Abstract

Three different analytical methods for the quality control of clozapine incommercial formulations were developed and compared: a liquid chromatographic (LC) method with UV detection, a capillary zone electrophoretic (CZE) method, and a linear scan voltammetric (LSV) method. The isocratic LC procedure used a C-18 reversed-phase column; the CZE method used an uncoated fused-silica capillary and phosphate buffer containing polyvinylpyrrolidone as the background electrolyte; the LSV method analyzed clozapine solutions with acidic phosphate buffer as the supporting electrolyte. The 3 methods gavesimilar and satisfactory results, in terms of precision and accuracy. Repeatability and intermediate precision were good (RSD% < 2.2) and accuracy, resulting from recovery studies, was between 98 and 102%. The rapidity of analysis was high for all 3 methods, especially for the LSV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 11:10:07