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Titolo:
Nasal allergen provocation induces adhesion molecule expression and tissueeosinophilia in upper and lower airways
Autore:
Braunstahl, GJ; Overbeek, SE; KleinJan, A; Prins, JB; Hoogsteden, HC; Fokkens, WJ;
Indirizzi:
Erasmus Univ, Med Ctr, Dept Otorhinolaryngol, Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands hinolaryngol, Rotterdam, Netherlands Erasmus Univ, Med Ctr, Dept Pulm Med, Rotterdam, Netherlands Erasmus UnivRotterdam Netherlands ept Pulm Med, Rotterdam, Netherlands
Titolo Testata:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
fascicolo: 3, volume: 107, anno: 2001,
pagine: 469 - 476
SICI:
0091-6749(200103)107:3<469:NAPIAM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL RESPONSIVENESS; RHINITIS PATIENTS; BONE-MARROW; E-SELECTIN; FOLLOW-UP; ASTHMA; CHALLENGE; INFLAMMATION; EOTAXIN; INCREASE;
Keywords:
allergic rhinitis; nasal provocation; bronchial inflammation; eosinophils; adhesion molecules; nose-lung interaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Braunstahl, GJ EMCR, Dept Pulm Med, H-Ee-22-63,Dr Molewaterpl 50, NL-3015 GE Rotterdam, Netherlands EMCR H-Ee-22-63,Dr Molewaterpl 50 Rotterdam Netherlands NL-3015 GE
Citazione:
G.J. Braunstahl et al., "Nasal allergen provocation induces adhesion molecule expression and tissueeosinophilia in upper and lower airways", J ALLERG CL, 107(3), 2001, pp. 469-476

Abstract

Background: Allergic rhinitis (AR) and asthma are characterized by means of a similar inflammatory process in which eosinophils are important effector cells. The migration of eosinophils from the blood into the tissues is dependent on adhesion molecules. Objective: To analyze the aspects of nasobronchial cross-talk, we studied the expression of adhesion molecules in nasal and bronchial mucosa after nasal allergen provocation (NP). Methods: Nine nonasthmatic subjects with seasonal AR and 9 healthy controlsubjects underwent NP out of season. Bronchial and nasal biopsy specimens were taken before (T-0) and 24 hours after NP (T-24). Mucosal sections wereanalyzed for the presence of eosinophils, IL-5, eotaxin, intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin, and human endothelium (CD31). Results: At T-24, an influx of eosinophils was detected in nasal epithelium (P = .01) and lamina propria (P < .01), as well as in bronchial epithelium (P = .05) and lamina propria (P < .05), of the patients with AR. At T-24,increased expression of ICAM-1, as well as increased percentages of ICAM-1(+), VCAM-1(+), and E-selectin(+) vessels, were seen in nasal and bronchialtissue of patients with AR. The number of mucosal eosinophils correlated with the local expression of ICAM-1, E-selectin, and VCAM-1 in patients withAR. Conclusion: This study shows that NP in patients with AR results in generalized airway inflammation through upregulation of adhesion molecules.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 15:24:50