Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Adverse outcomes in a controlled trial of pergolide for cocaine dependence
Autore:
Malcolm, R; Herron, J; Sutherland, SE; Brady, KT;
Indirizzi:
Med Univ S Carolina, Dept Biometry & Epidemiol, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 iol, Charleston, SC 29425 USA Miss St Josephs, Asheville, NC 28801 USA Miss St Josephs Asheville NC USA28801 t Josephs, Asheville, NC 28801 USA
Titolo Testata:
JOURNAL OF ADDICTIVE DISEASES
fascicolo: 1, volume: 20, anno: 2001,
pagine: 81 - 92
SICI:
1055-0887(2001)20:1<81:AOIACT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-RECEPTOR AGONISTS; SEEKING BEHAVIOR; DOUBLE-BLIND; BROMOCRIPTINE; AMANTADINE; WITHDRAWAL; MESYLATE; ABUSE;
Keywords:
pergolide; treatment; cocaine dependence; dopamine agonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Malcolm, R Med Univ S Carolina, Dept Biometry & Epidemiol, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 ston, SC 29425 USA
Citazione:
R. Malcolm et al., "Adverse outcomes in a controlled trial of pergolide for cocaine dependence", J ADDICT D, 20(1), 2001, pp. 81-92

Abstract

We conducted a double-blind, multiple dose comparison study of pergolide versus placebo for the treatment of cocaine dependence. In the present study, we examined patients who met criteria for cocaine dependence without comorbid alcohol dependence (N = 255). Study completion rates favored placebo (48.9%) over the low dose (3.3.3%) and high dose (21.5%) pergolide subjects (chi (2)(2) = 14.17, p less than or equal to 0.001). Treatment effectiveness scores (TES) were significantly higher for the placebo group (31.7) than the low dose (25.2) and high dose (14.2) pergolide groups (F2,252 = 6.21, p= 0.002). There were no significant differences in side effect profiles after first dose of pergolide or placebo, or at study termination. Results ofthis study suggest that pergolide was not efficacious in the treatment of cocaine dependence due to reduced study participation. Caution regarding the outpatient use of pergolide in similar populations is warranted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:45:52