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Titolo:
Lack of tyrosine protein kinase regulation of L-type Ca2+ channel current in transfected cells stably expressing alpha(1C-b) subunit
Autore:
Sunagawa, M; Nakamura, M; Kosugi, T; Hofmann, F; Sperelakis, N;
Indirizzi:
Univ Ryukyus, Dept Physiol 1, Sch Med, Nishihara, Okinawa 9030215, Japan Univ Ryukyus Nishihara Okinawa Japan 9030215 hara, Okinawa 9030215, Japan Univ Cincinnati, Coll Med, Dept Mol & Cellular Physiol, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Physiol, Cincinnati, OH 45267 USA Tech Univ Munich, Inst Pharmakol & Toxikol, D-80802 Munich, Germany Tech Univ Munich Munich Germany D-80802 Toxikol, D-80802 Munich, Germany
Titolo Testata:
JAPANESE JOURNAL OF PHYSIOLOGY
fascicolo: 1, volume: 51, anno: 2001,
pagine: 115 - 119
SICI:
0021-521X(200102)51:1<115:LOTPKR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; CALCIUM; PP60(C-SRC);
Keywords:
L-type Ca2+ channel; vascular smooth muscle cells; COS-7 cells; whole-cell voltage clamp; tyrosine protein kinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Sunagawa, M Univ Ryukyus, Dept Physiol 1, Sch Med, 207 Uehara, Nishihara, Okinawa 9030215, Japan Univ Ryukyus 207 Uehara Nishihara Okinawa Japan 9030215 Japan
Citazione:
M. Sunagawa et al., "Lack of tyrosine protein kinase regulation of L-type Ca2+ channel current in transfected cells stably expressing alpha(1C-b) subunit", JPN J PHYSL, 51(1), 2001, pp. 115-119

Abstract

Tyrosine protein kinase (Tyr-PK) regulation of L-type Ca2+ channel (Ca-L) current was studied in COS-7 cells expressing vascular smooth muscle-type alpha (1C-b) with no auxiliary subunit by using a whole-cell voltage clamp. The averaged peak amplitude of Cat currents was -0.33 +/-0.03 at holding potential of -60mV. Na3VO4 genistein and phosphorylated p60(c-src) peptide had no effect on the current. Thus the alpha (1C-b) subunif may not be involved in Tyr-PK regulation of Ca-L current.

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Documento generato il 29/09/20 alle ore 10:27:55