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Titolo:
Effects of aging on the electroretionogram during ischemia-reperfusion in rats
Autore:
Katano, H; Ishihara, M; Shiraishi, Y; Kawai, Y;
Indirizzi:
Tottori Univ, Fac Med, Dept Physiol, Yonago, Tottori 6838503, Japan Tottori Univ Yonago Tottori Japan 6838503 Yonago, Tottori 6838503, Japan Tottori Univ, Fac Med, Dept Ophthalmol, Yonago, Tottori 6838503, Japan Tottori Univ Yonago Tottori Japan 6838503 Yonago, Tottori 6838503, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHYSIOLOGY
fascicolo: 1, volume: 51, anno: 2001,
pagine: 89 - 97
SICI:
0021-521X(200102)51:1<89:EOAOTE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; RETINAL ISCHEMIA; BLOOD-FLOW; POSTISCHEMIC REPERFUSION; INTRAOCULAR-PRESSURE; RABBIT; ELECTRORETINOGRAM; EYES; INHIBITION; CATS;
Keywords:
aging; choroidal blood flow; electroretinogram; ischemia; reperfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Kawai, Y Tottori Univ, Fac Med, Dept Physiol, 86 Nishi Cho, Yonago, Tottori 6838503, Japan Tottori Univ 86 Nishi Cho Yonago Tottori Japan 6838503 503, Japan
Citazione:
H. Katano et al., "Effects of aging on the electroretionogram during ischemia-reperfusion in rats", JPN J PHYSL, 51(1), 2001, pp. 89-97

Abstract

The effects of aging on the electroretinogram (ERG) during ischemia-reperfusion were investigated in rats. Flash-elicited ERG (a-wave, b-wave, and oscillatory potentials (OPs)) was recorded in young (4 months old) and aged rats (over 18 months old) before, during, and after exposure to 30- or 120-min ischemia induced by increasing intraocular pressure to 80mmHg. The choroidal blood flow, measured by means of laser Doppler flowmetry, decreased to40 to 60% of the baseline value during ischemia, Young rats showed no significant difference in the amplitude of each ERG component during ischemia between 30- and 120-min ischemia groups; 78.0 +/-4.9 vs. 76.1 +/-3.6% for a-wave, 63.4 +/-3.1 vs. 60.6 +/-3.0% for b-wave, and 59.6 +/-5.9 vs. 57.5 +/-6.7% for Sigma OP. In aged rats, however, 120-min ischemia caused a greaterdecrease, to 56.7 +/-3.1% of the baseline value, in the a-wave amplitude than 30-min ischemia did, to 70.8 +/-3.2%. The reduction of each ERG component in both 30- and 120-min ischemia experiments was greater in aged rats than in young rats. The recovery time for the amplitude of each ERG componentduring reperfusion was longer in aged rats than in young rats. The latencyof b-wave and the second component of OPs prolonged during ischemia, and recovery time for the latency was longer in aged rats than in young rats. These results suggest that the electrophysiological function of the retina isless tolerable against ischemia-reperfusion in aged rats than in young rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:34:13