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Titolo:
A study of pretreatment nomograms to predict pathological stage and biochemical recurrence after radical prostatectomy for clinically resectable prostate cancer in Japanese men
Autore:
Egawa, S; Suyama, K; Arai, Y; Matsumoto, K; Tsukayama, C; Kuwao, S; Baba, S;
Indirizzi:
Kitasato Univ, Sch Med, Dept Urol, Sagamihara, Kanagawa 2288555, Japan Kitasato Univ Sagamihara Kanagawa Japan 2288555 , Kanagawa 2288555, Japan
Titolo Testata:
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
fascicolo: 2, volume: 31, anno: 2001,
pagine: 74 - 81
SICI:
0368-2811(200102)31:2<74:ASOPNT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEAM RADIATION-THERAPY; GLEASON SCORE; ANTIGEN; INVOLVEMENT;
Keywords:
prostate cancer; nomogram; pathological stage; biochemical failure; radical prostatectomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Egawa, S Kitasato Univ, Sch Med, Dept Urol, 1-5-1 Kitasato, Sagamihara, Kanagawa 2288555, Japan Kitasato Univ 1-5-1 Kitasato Sagamihara Kanagawa Japan 2288555 an
Citazione:
S. Egawa et al., "A study of pretreatment nomograms to predict pathological stage and biochemical recurrence after radical prostatectomy for clinically resectable prostate cancer in Japanese men", JPN J CLIN, 31(2), 2001, pp. 74-81

Abstract

Background: Accurate pretreatment identification of the risks that prostate cancer has extended beyond the gland and that it will recur would significantly influence practice patterns. Preoperative nomograms to predict such risks have not been developed for the oriental male population. Methods: Construction of nomograms to predict preoperatively pathological outcome and early biochemical failure following radical prostatectomy in Japanese males was based on logistic regression analysis, with predicted probabilities and 95% confidence intervals for the final model being obtained by repeating the analysis on 1000 bootstrap samples from the original cohort. Results: Prostate-specific antigen level, clinical stage and biopsy Gleason score contributed significantly to the prediction of pathological stage and of biochemical failure in the univariate analysis (p < 0.001). Combined use of these three variables predicted these treatment outcomes better thanany single variable (p < 0.001). Nomograms combining these three variablesto predict final pathological findings and early biochemical failure were then developed. The medians and 95% confidence intervals of the predicted probabilities are presented in the nomograms. Conclusions: This information enables clinicians to use their nomograms when counseling Japanese patients, leading to more informed treatment decisions and helping to identify those with a high risk of early biochemical failure. The nomograms may also be used to assure comparability of different treatment modalities in investigational trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:48:51