Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Differentiation of radiographically indeterminate solitary pulmonary nodules with [F-18]fluoro-2-deoxyglucose positron emission tomography
Autore:
Hung, GU; Shiau, YC; Tsai, SC; Ho, YJ; Kao, CH; Yen, RF;
Indirizzi:
Taichung Vet Gen Hosp, Dept Nucl Med, Sect 3, Taichung 407, Taiwan Taichung Vet Gen Hosp Taichung Taiwan 407 , Sect 3, Taichung 407, Taiwan
Titolo Testata:
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
fascicolo: 2, volume: 31, anno: 2001,
pagine: 51 - 54
SICI:
0368-2811(200102)31:2<51:DORISP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
FDG-PET; F-18 FLUORODEOXYGLUCOSE; BRONCHOGENIC-CARCINOMA; LUNG-CANCER; FLUORINE-18-FDG; MALIGNANCY; LESIONS; CT;
Keywords:
[F-18]fluoro-2-deoxyglucose; positron emission tomography; indeterminate solitary pulmonary nodules;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kao, CH Taichung Vet Gen Hosp, Dept Nucl Med, Sect 3, 160 Taichung Harbor Rd, Taichung 407, Taiwan Taichung Vet Gen Hosp 160 Taichung Harbor Rd Taichung Taiwan 407
Citazione:
G.U. Hung et al., "Differentiation of radiographically indeterminate solitary pulmonary nodules with [F-18]fluoro-2-deoxyglucose positron emission tomography", JPN J CLIN, 31(2), 2001, pp. 51-54

Abstract

Background: The purpose of this preliminary study was to evaluate the efficacy of positron emission tomography (PET) with [F-18]fluoro-2-deoxyglucose(FDG) for differentiating benign from malignant solitary pulmonary nodules. Methods: Twenty-six patients (12 females, 14 males, age 27-79 years) with radiographically indeterminate solitary pulmonary nodules underwent FDG-PETand the findings were compared with the results of pathological examination of biopsy samples. FDG activity in the lesion was expressed as the ratio of lesion-to-background counts (L/B ratio) for semiquantitative analysis. Results: The mean L/B ratio of malignant lesions (8.81 +/- 3.71, n = 20) was not significantly higher than that of benign lesions (4.71 +/- 3.00, n =6) (p = 1.00). Using a cut-off L/B ratio of 5.0 for malignancy, FDG-PET correctly detected 19 true positive and three true negative cases, but failedto detect three false positive (two abscesses and one cryptococcus) cases and one false negative (adenocarcinoma) case. The sensitivity, specificity,accuracy, positive predictive value and negative predictive value were 95,50, 86, 75 and 85%, respectively. Conclusions: FDG-PET is a sensitive modality for detecting malignancy, butis not specific enough. Benign lung lesion with active inflammation could demonstrate high FDG uptake, making it difficult to differentiate from malignancy. In the future, we will increase the case numbers to evaluate further the utility of FDG-PET for differentiating radiographically indeterminatesolitary pulmonary nodules.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/05/20 alle ore 01:33:54